| ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFbetaR1 ISGylation. | ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation.
Cui N, Liu C, Tang X, Song L, Xiao Z, Wang C, Wu Y, Zhou Y, Peng C, Liu Y, Zheng L, Liu X, Huang K, Chen H., Free PMC Article | 08/9/2024 |
| ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection. | ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection.
Bredow C, Thery F, Wirth EK, Ochs S, Kespohl M, Kleinau G, Kelm N, Gimber N, Schmoranzer J, Voss M, Klingel K, Spranger J, Renko K, Ralser M, Mülleder M, Heuser A, Knobeloch KP, Scheerer P, Kirwan J, Brüning U, Berndt N, Impens F, Beling A., Free PMC Article | 05/30/2024 |
| Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. | Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage.
Homma H, Yoshioka Y, Fujita K, Shirai S, Hama Y, Komano H, Saito Y, Yabe I, Okano H, Sasaki H, Tanaka H, Okazawa H., Free PMC Article | 04/24/2024 |
| Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1alpha signalling pathway. | Increase of ISG15 in psoriasis lesions and its promotion of keratinocyte proliferation via the Hif-1α signalling pathway.
Sun X, Li Y. | 11/7/2023 |
| ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions. | ISG15 Is Required for the Dissemination of Vaccinia Virus Extracellular Virions.
Bécares M, Albert M, Tárrega C, Coloma R, Falqui M, Luhmann EK, Radoshevich L, Guerra S., Free PMC Article | 08/24/2023 |
| ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma. | ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma.
Qu T, Zhang W, Yan C, Ren D, Wang Y, Guo Y, Guo Q, Wang J, Liu L, Han L, Li L, Huang Q, Cao L, Ye Z, Zhang B, Zhao Q, Cao W., Free PMC Article | 05/31/2023 |
| Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure. | Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure.
Yerra VG, Batchu SN, Kaur H, Kabir MDG, Liu Y, Advani SL, Tran DT, Sadeghian S, Sedrak P, Billia F, Kuzmanov U, Gramolini AO, Qasrawi DO, Petrotchenko EV, Borchers CH, Connelly KA, Advani A., Free PMC Article | 05/3/2023 |
| ISGylation of NF-kappaBp65 by SCF[FBXL19] E3 Ligase Diminishes Endothelial Inflammation. | ISGylation of NF-κBp65 by SCF(FBXL19) E3 Ligase Diminishes Endothelial Inflammation.
Li L, Miao J, Shaheen N, Taleb SJ, Hu J, Ye Q, He J, Yan J, Mallampalli RK, Zhao J, Zhao Y., Free PMC Article | 05/1/2023 |
| Free ISG15 inhibits Pseudorabies virus infection by positively regulating type I IFN signaling. | Free ISG15 inhibits Pseudorabies virus infection by positively regulating type I IFN signaling.
Liu H, Li C, He W, Chen J, Yang G, Chen L, Chang H., Free PMC Article | 11/19/2022 |
| Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages. | Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages.
Cao S, Dou X, Zhang X, Fang Y, Yang Z, Jiang Y, Hao X, Zhang Z, Wang H. | 12/25/2021 |
| IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. | IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis.
Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, Chouchani E, Ahmad R, Rosen ED., Free PMC Article | 10/2/2021 |
| Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15. | Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15.
Kong E, Kim HD, Kim J., Free PMC Article | 09/25/2021 |
| Evidence for an involvement of the ubiquitin-like modifier ISG15 in MHC class I antigen presentation. | Evidence for an involvement of the ubiquitin-like modifier ISG15 in MHC class I antigen presentation.
Held T, Basler M, Knobeloch KP, Groettrup M. | 04/24/2021 |
| IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell-Dependent Route. | IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell-Dependent Route.
Iglesias-Guimarais V, Ahrends T, de Vries E, Knobeloch KP, Volkov A, Borst J., Free PMC Article | 01/2/2021 |
| Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming. | Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming.
Kespohl M, Bredow C, Klingel K, Voß M, Paeschke A, Zickler M, Poller W, Kaya Z, Eckstein J, Fechner H, Spranger J, Fähling M, Wirth EK, Radoshevich L, Thery F, Impens F, Berndt N, Knobeloch KP, Beling A., Free PMC Article | 11/21/2020 |
| ISG15 Acts as a Mediator of Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6J Mouse Corneas. | ISG15 Acts as a Mediator of Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6J Mouse Corneas.
Gao N, Me R, Dai C, Yu FX., Free PMC Article | 10/3/2020 |
| ISG15 modifies extracellular and mitochondrial proteins during Listeria monocytogenes infection. | The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection.
Zhang Y, Thery F, Wu NC, Luhmann EK, Dussurget O, Foecke M, Bredow C, Jiménez-Fernández D, Leandro K, Beling A, Knobeloch KP, Impens F, Cossart P, Radoshevich L., Free PMC Article | 04/18/2020 |
| this study shows that cysteine-reactive free ISG15 generates IL-1beta-producing CD8alpha(+) dendritic cells at the site of infection | Cysteine-Reactive Free ISG15 Generates IL-1β-Producing CD8α(+) Dendritic Cells at the Site of Infection.
Napolitano A, van der Veen AG, Bunyan M, Borg A, Frith D, Howell S, Kjaer S, Beling A, Snijders AP, Knobeloch KP, Frickel EM., Free PMC Article | 07/6/2019 |
| ISGylation is a ubiquitin-like modification that controls exosome release. ISGylation induction decreases microvesicular body numbers and impairs exosome secretion. Specifically, ISGylation of the MVB protein TSG101 induces its aggregation and degradation, being sufficient to impair exosome secretion. | ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins.
Villarroya-Beltri C, Baixauli F, Mittelbrunn M, Fernández-Delgado I, Torralba D, Moreno-Gonzalo O, Baldanta S, Enrich C, Guerra S, Sánchez-Madrid F., Free PMC Article | 09/29/2018 |
| Murine Isg15 does not control Usp18 accumulation and IFN-alpha/beta signaling. | ISG15 deficiency and increased viral resistance in humans but not mice.
Speer SD, Li Z, Buta S, Payelle-Brogard B, Qian L, Vigant F, Rubino E, Gardner TJ, Wedeking T, Hermann M, Duehr J, Sanal O, Tezcan I, Mansouri N, Tabarsi P, Mansouri D, Francois-Newton V, Daussy CF, Rodriguez MR, Lenschow DJ, Freiberg AN, Tortorella D, Piehler J, Lee B, García-Sastre A, Pellegrini S, Bogunovic D., Free PMC Article | 09/22/2018 |
| Extracellular ISG15 signals cytokine secretion through the LFA-1 integrin receptor (CD11a/CD18) in natural killer cells. | Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor.
Swaim CD, Scott AF, Canadeo LA, Huibregtse JM., Free PMC Article | 11/25/2017 |
| results demonstrate that ISG15 governs the dynamic functionality of mitochondria, specifically, OXPHOS and mitophagy, broadening its physiological role as an antiviral agent. | ISG15 governs mitochondrial function in macrophages following vaccinia virus infection.
Baldanta S, Fernández-Escobar M, Acín-Perez R, Albert M, Camafeita E, Jorge I, Vázquez J, Enríquez JA, Guerra S., Free PMC Article | 11/4/2017 |
| Loss of ISG15 expression and type I IFN signaling have transient effects on bacterial burden during M. tuberculosis infection in mice | The impact of ISGylation during Mycobacterium tuberculosis infection in mice.
Kimmey JM, Campbell JA, Weiss LA, Monte KJ, Lenschow DJ, Stallings CL., Free PMC Article | 10/14/2017 |
| ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis. | ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis.
Dong C, Gao N, Ross BX, Yu FX., Free PMC Article | 07/22/2017 |
| USP18's ISG15 specificity is mediated by a small interaction interface. | Structural basis of the specificity of USP18 toward ISG15.
Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G., Free PMC Article | 06/24/2017 |