XPO1A exportin 1A [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: XPO1A
Official Full Name: exportin 1A
Primary source: TAIR:AT5G17020
Locus tag: AT5G17020
See related: Araport:AT5G17020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA EXPORTIN 1; ATCRM1; ATXPO1; EXPORTIN 1; exportin 1A; F2K13.170; F2K13_170; HEAT-INTOLERANT 2; HIT2; XPO1
Summary: Encodes a member of the exportin protein family (XPO1A) which functions as receptors for nuclear export. Binds to a variety of proteins having leucine rich export signals.Along with XPO1B involved with development of the male and female gametophytes.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See XPO1A in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 32

Sequence:: Chromosome: 5; NC_003076.8 (5594632..5602969)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XPO1A directly interacts with histone deacetylase HDA6 in vivo and that the xpo1a mutation causes increased nuclear retention of HDA6 protein
Title: EXPORTIN 1A prevents transgene silencing in Arabidopsis by modulating nucleo-cytoplasmic partitioning of HDA6.
The results provide evidence that Arabidopsis XPO1A is dispensable for normal plant growth and development but is essential for thermotolerance, in part by mediating the protection of plants against heat-induced oxidative stress.
Title: Isolation and characterization of the Arabidopsis heat-intolerant 2 (hit2) mutant reveal the essential role of the nuclear export receptor EXPORTIN1A (XPO1A) in plant heat tolerance.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001203395.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables nuclear export signal receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo sac development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pollen development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pollen germination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pollen tube growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: exportin 1A

NP_001190324.1

exportin 1A (XPO1A); CONTAINS InterPro DOMAIN/s: Importin-beta, N-terminal (InterPro:IPR001494), Exportin 1, C-terminal (InterPro:IPR014877), Armadillo-like helical (InterPro:IPR011989), Exportin-1/Importin-beta-like (InterPro:IPR013598), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: exportin 1B (TAIR:AT3G03110.1).

NP_197204.1

exportin 1A (XPO1A); CONTAINS InterPro DOMAIN/s: Importin-beta, N-terminal (InterPro:IPR001494), Exportin 1, C-terminal (InterPro:IPR014877), Exportin-1/Importin-beta-like (InterPro:IPR013598), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: exportin 1B (TAIR:AT3G03110.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

5594632..5602969

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_121708.3 → NP_197204.1 exportin 1A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197204.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4KFL2, Q9SMV6

UniProtKB/TrEMBL

A0A178U9W2, A0A5S9Y5N4

Conserved Domains (1) summary

COG5101
Location:4 → 1044

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
NM_001203395.1 → NP_001190324.1 exportin 1A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190324.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SMV6

Conserved Domains (4) summary

COG5101
Location:4 → 1029

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

pfam03810
Location:37 → 103

IBN_N; Importin-beta N-terminal domain

pfam08389
Location:114 → 258

Xpo1; Exportin 1-like protein

pfam08767
Location:697 → 1018

CRM1_C; CRM1 C terminal