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    NTRC NADPH-dependent thioredoxin reductase C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818766, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NTRC
    Official Full Name
    NADPH-dependent thioredoxin reductase C
    Primary source
    TAIR:AT2G41680
    Locus tag
    AT2G41680
    See related
    Araport:AT2G41680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    NADPH-dependent thioredoxin reductase C; T32G6.20; T32G6_20
    Summary
    Encodes a NADPH thioredoxin reductase involved in chloroplast protection against oxidative damage.
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    Genomic context

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    See NTRC in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (17376155..17379059, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene MIZU-KUSSEI-like protein (Protein of unknown function, DUF617) Neighboring gene ncRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene heat shock transcription factor B3 Neighboring gene ATP-binding cassette A1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two chloroplast thioredoxin systems differentially modulate photosynthesis in Arabidopsis depending on light intensity and leaf age. Guinea Diaz M, et al. Plant J, 2020 Nov. PMID 32772439, Free PMC Article
    2. NADPH-dependent thioredoxin reductase and 2-Cys peroxiredoxins are needed for the protection of Mg-protoporphyrin monomethyl ester cyclase. Stenbaek A, et al. FEBS Lett, 2008 Aug 6. PMID 18625226
    3. Chloroplast NADPH-thioredoxin reductase interacts with photoperiodic development in Arabidopsis. Lepistö A, et al. Plant Physiol, 2009 Mar. PMID 19151130, Free PMC Article
    4. NTRC links built-in thioredoxin to light and sucrose in regulating starch synthesis in chloroplasts and amyloplasts. Michalska J, et al. Proc Natl Acad Sci U S A, 2009 Jun 16. PMID 19470473, Free PMC Article
    5. NADPH thioredoxin reductase C is localized in plastids of photosynthetic and nonphotosynthetic tissues and is involved in lateral root formation in Arabidopsis. Kirchsteiger K, et al. Plant Cell, 2012 Apr. PMID 22505729, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cystathionine-beta-synthase X proteins negatively regulate NADPH-thioredoxin reductase C activity.
      Title: Cystathionine-β-synthase X proteins negatively regulate NADPH-thioredoxin reductase C activity.
    2. Two chloroplast thioredoxin systems differentially modulate photosynthesis in Arabidopsis depending on light intensity and leaf age.
      Title: Two chloroplast thioredoxin systems differentially modulate photosynthesis in Arabidopsis depending on light intensity and leaf age.
    3. Insights into the function of NADPH thioredoxin reductase C (NTRC) based on identification of NTRC-interacting proteins in vivo.
      Title: Insights into the function of NADPH thioredoxin reductase C (NTRC) based on identification of NTRC-interacting proteins in vivo.
    4. important mediator of plant responses to microbial volatile compounds through mechanisms involving global thiol redox proteome changes that affect photosynthesis
      Title: Plant responses to fungal volatiles involve global posttranslational thiol redox proteome changes that affect photosynthesis.
    5. NTRC plays a pivotal role in chloroplast redox regulation, being necessary for the activity of diverse thioredoxins with unrelated functions.
      Title: NADPH Thioredoxin Reductase C and Thioredoxins Act Concertedly in Seedling Development.
    6. NTRC-mediated regulation of the Calvin-Benson cycle and ATP synthesis occurs both directly and through interaction with the ferredoxin-thioredoxin system and is crucial when availability of light is limiting photosynthesis.
      Title: Crosstalk between chloroplast thioredoxin systems in regulation of photosynthesis.
    7. NTRC is highly sensitive to rapidly changing light intensities.NTRC is not responsible for 'metabolism-related' regulation of the ATP synthase.
      Title: Multi-level regulation of the chloroplast ATP synthase: the chloroplast NADPH thioredoxin reductase C (NTRC) is required for redox modulation specifically under low irradiance.
    8. cooperative control of chloroplast functions via the FTR/Trx and NTRC pathways is essential for plant viability
      Title: Two distinct redox cascades cooperatively regulate chloroplast functions and sustain plant viability.
    9. These data uncover a new role for NTRC in the control of photosynthetic yield.
      Title: The chloroplast NADPH thioredoxin reductase C, NTRC, controls non-photochemical quenching of light energy and photosynthetic electron transport in Arabidopsis.
    10. An Arabidopsis thaliana double knockout mutant lacking NTRC and Srx shows a phenotype similar to the ntrc mutant, while the srx mutant resembles wild-type plants. NTRC deficiency causes reduced overoxidation of 2-Cys peroxiredoxins.
      Title: The contribution of NADPH thioredoxin reductase C (NTRC) and sulfiredoxin to 2-Cys peroxiredoxin overoxidation in Arabidopsis thaliana chloroplasts.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129731.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of catalytic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of starch biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    NADPH-dependent thioredoxin reductase C
    NP_565954.1
    • NADPH-dependent thioredoxin reductase C (NTRC); FUNCTIONS IN: thioredoxin-disulfide reductase activity; INVOLVED IN: hydrogen peroxide catabolic process; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridine nucleotide-disulphide oxidoreductase, class-II (InterPro:IPR000103), FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Thioredoxin fold (InterPro:IPR012335), Thioredoxin reductase (InterPro:IPR005982), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Pyridine nucleotide-disulphide oxidoreductase, class-II, active site (InterPro:IPR008255), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: NADPH-dependent thioredoxin reductase A (TAIR:AT2G17420.1); Has 36111 Blast hits to 36072 proteins in 3191 species: Archae - 926; Bacteria - 24476; Metazoa - 1051; Fungi - 742; Plants - 985; Viruses - 7; Other Eukaryotes - 7924 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17376155..17379059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129731.6 → NP_565954.1  NADPH-dependent thioredoxin reductase C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22229, Q0WM62, Q93ZQ1
      UniProtKB/TrEMBL
      A0A178VZE7, A0A5S9X684, A0A7G2EHD5
      Conserved Domains (2) summary
      cd02949
      Location:430 → 526
      TRX_NTR; TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible ...
      TIGR01292
      Location:86 → 391
      TRX_reduct; thioredoxin-disulfide reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22229.2

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