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    smal smoke alarm [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smalprovided by FlyBase
    Official Full Name
    smoke alarmprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085409
    Locus tag
    Dmel_CG34380
    See related
    AllianceGenome:FB:FBgn0085409
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0073329.6; CG13986; CG13987; CG13988; CG15813; CG31640; CG34380; Dmel\CG34380
    Old locus tag
    CG13988; CG31640; Dmel_CG13988; Dmel_CG31640
    Summary
    Predicted to enable collagen binding activity. Is expressed in several structures, including adult brain; adult head; antennal anlage; endoderm anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in several diseases, including alcoholic liver cirrhosis; bone disease (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and skin melanoma. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1) and DDR2 (discoidin domain receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See smal in Genome Data Viewer
    Location:
    26B10-26B11; 2-18 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6179133..6211114)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6179133..6211114)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44823 Neighboring gene UDP-glycosyltransferase family 37 member B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring Regulators. Li J, et al. Cell, 2020 Jan 23. PMID 31955847, Free PMC Article
    2. Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Lavoy S, et al. Genetics, 2018 Aug. PMID 29907646, Free PMC Article
    3. A kinase-dependent feedforward loop affects CREBB stability and long term memory formation. Lee PT, et al. Elife, 2018 Feb 23. PMID 29473541, Free PMC Article
    4. Identification and functional analysis of healing regulators in Drosophila. Álvarez-Fernández C, et al. PLoS Genet, 2015. PMID 25647511, Free PMC Article
    5. A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. Hadar N, et al. Gene, 2012 Feb 15. PMID 22192913

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables collagen binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    smoke alarm
    Names
    CG34380-PC
    CG34380-PD
    CG34380-PE
    smal-PC
    smal-PD
    smal-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6179133..6211114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164688.2 → NP_723165.2  smoke alarm, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723165.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY37
      Conserved Domains (2) summary
      smart00231
      Location:78 → 234
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:81 → 233
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    2. NM_001273195.1 → NP_001260124.1  smoke alarm, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYR2
      Conserved Domains (2) summary
      smart00231
      Location:78 → 234
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:81 → 233
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    3. NM_001103627.4 → NP_001097097.1  smoke alarm, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYR2
      Conserved Domains (2) summary
      smart00231
      Location:78 → 234
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:81 → 233
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYR2 A8DYR2
    Q8MYY4 Q8MYY4
    R9PY37 R9PY37

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