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    marco macrophage receptor with collagenous structure [ Danio rerio (zebrafish) ]

    Gene ID: 571584, updated on 4-Jan-2025

    Summary

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    Official Symbol
    marcoprovided by ZNC
    Official Full Name
    macrophage receptor with collagenous structureprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120514-2
    See related
    Ensembl:ENSDARG00000059294 AllianceGenome:ZFIN:ZDB-GENE-120514-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Acts upstream of or within defense response to bacterium and phagocytosis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human MARCO (macrophage receptor with collagenous structure). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See marco in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (795678..813533, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (796045..813953, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101883921 Neighboring gene engrailed homeobox 1a Neighboring gene complement component 1, q subcomponent-like 2 Neighboring gene putative C-type lectin domain family 20 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish as a Vertebrate Model for Studying Nodavirus Infections. Lama R, et al. Front Immunol, 2022. PMID 35401537, Free PMC Article
    2. Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish. Botthof JG, et al. Proc Natl Acad Sci U S A, 2017 May 30. PMID 28512217, Free PMC Article
    3. Comparative transcriptome analysis of zebrafish (Danio rerio) brain and spleen infected with spring viremia of carp virus (SVCV). Wang Y, et al. Fish Shellfish Immunol, 2017 Oct. PMID 28757199
    4. Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Verwilligen RAF, et al. Atherosclerosis, 2022 Apr. PMID 35247629
    5. A csf1rb mutation uncouples two waves of microglia development in zebrafish. Ferrero G, et al. Development, 2021 Jan 11. PMID 33298459

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signaling.
      Title: Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    macrophage receptor MARCO

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      795678..813533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009304404.4 → XP_009302679.1  macrophage receptor MARCO isoform X3

      UniProtKB/TrEMBL
      A0A8M3BC80, A0A8M9QFQ5, F1QU19
      Related
      ENSDARP00000076803.4, ENSDART00000082368.5
      Conserved Domains (3) summary
      pfam01391
      Location:159 → 226
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:355 → 449
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:360 → 450
      SRCR; Scavenger receptor cysteine-rich domain

    2. XM_068223529.1 → XP_068079630.1  macrophage receptor MARCO isoform X6

      UniProtKB/TrEMBL
      A0A8M9QFQ5

    3. XM_068223528.1 → XP_068079629.1  macrophage receptor MARCO isoform X5

      UniProtKB/TrEMBL
      A0A286YAI0, A0A8M3AVP8, A0A8M9QFQ5
      Related
      ENSDARP00000144174.1, ENSDART00000174793.2

    4. XM_009304405.4 → XP_009302680.1  macrophage receptor MARCO isoform X4

      UniProtKB/TrEMBL
      A0A286YAI0, A0A8M3AVP8, A0A8M9QFQ5
      Conserved Domains (3) summary
      pfam01391
      Location:159 → 226
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:355 → 449
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:360 → 450
      SRCR; Scavenger receptor cysteine-rich domain

    5. XM_068223527.1 → XP_068079628.1  macrophage receptor MARCO isoform X2

      UniProtKB/TrEMBL
      A0A8M9QFQ5

    6. XM_005169122.5 → XP_005169179.1  macrophage receptor MARCO isoform X1

      UniProtKB/TrEMBL
      A0A8M2BH24, A0A8M9QFQ5
      Conserved Domains (3) summary
      pfam01391
      Location:177 → 236
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:441 → 535
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:446 → 536
      SRCR; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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