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    stk36 serine/threonine kinase 36 (fused homolog, Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 566154, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stk36provided by ZNC
    Official Full Name
    serine/threonine kinase 36 (fused homolog, Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030912-6
    See related
    Ensembl:ENSDARG00000061095 AllianceGenome:ZFIN:ZDB-GENE-030912-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fu; zgc:152944; si:dkey-180i4.3
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within axoneme assembly; regionalization; and smoothened signaling pathway. Predicted to be active in cytoplasm. Is expressed in neural tube. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See stk36 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (30392149..30411186)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (29792000..29811100)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:158412 Neighboring gene grass carp reovirus (GCRV)-induced gene 2o Neighboring gene activating transcription factor 5a Neighboring gene pleckstrin homology-like domain, family B, member 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The medaka dhc2 mutant reveals conserved and distinct mechanisms of Hedgehog signaling in teleosts. Yamamoto T, et al. BMC Dev Biol, 2015 Feb 3. PMID 25645819, Free PMC Article
    2. Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo. Wolff C, et al. Curr Biol, 2003 Jul 15. PMID 12867027
    3. Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish. Terhune EA, et al. Hum Mutat, 2021 Apr. PMID 33382518, Free PMC Article
    4. The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Xia L, et al. Cell, 2010 Dec 10. PMID 21145463
    5. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Wilson CW, et al. Nature, 2009 May 7. PMID 19305393, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. zebrafish Fu is required both for Hh signalling and cilia biogenesis in Kupffer's vesicle [fused]
      Title: Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC152944

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 36
    Names
    fused
    NP_001071039.2
    XP_009299810.1
    XP_009299811.1
    XP_068077365.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077571.2 → NP_001071039.2  serine/threonine-protein kinase 36

      See identical proteins and their annotated locations for NP_001071039.2

      Status: PROVISIONAL

      Source sequence(s)
      BC154435
      UniProtKB/TrEMBL
      A0A8M1NBU0, A8WFS2
      Related
      ENSDARP00000081199.4, ENSDART00000086765.5
      Conserved Domains (2) summary
      smart00220
      Location:4 → 254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2 → 254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      30392149..30411186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221264.1 → XP_068077365.1  serine/threonine-protein kinase 36 isoform X3

    2. XM_009301535.3 → XP_009299810.1  serine/threonine-protein kinase 36 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B9P5
      Conserved Domains (2) summary
      smart00220
      Location:4 → 254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2 → 254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

    3. XM_009301536.3 → XP_009299811.1  serine/threonine-protein kinase 36 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ASI9
      Conserved Domains (2) summary
      smart00220
      Location:4 → 254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2 → 254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
    Nucleotide Protein Strain
    Heading Accession and Version

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