U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MMP19 matrix metallopeptidase 19 [ Homo sapiens (human) ]

    Gene ID: 4327, updated on 3-Dec-2024

    Summary

    Official Symbol
    MMP19provided by HGNC
    Official Full Name
    matrix metallopeptidase 19provided by HGNC
    Primary source
    HGNC:HGNC:7165
    See related
    Ensembl:ENSG00000123342 MIM:601807; AllianceGenome:HGNC:7165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CODA; MMP18; RASI-1
    Summary
    This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
    Expression
    Broad expression in gall bladder (RPKM 58.3), appendix (RPKM 21.2) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MMP19 in Genome Data Viewer
    Location:
    12q13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (55835433..55842936, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (55802080..55809587, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56229217..56236720, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 11 Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:56192003-56192504 Neighboring gene ORMDL sphingolipid biosynthesis regulator 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4538 Neighboring gene DnaJ heat shock protein family (Hsp40) member C14 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56223947-56224684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6460 Neighboring gene transmembrane protein 198B (pseudogene) Neighboring gene RNA, 7SL, cytoplasmic 676, pseudogene Neighboring gene OLA1 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in luteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ovulation from ovarian follicle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hormone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-19
    Names
    matrix metalloproteinase RASI
    matrix metalloproteinase-18
    matrix metalloproteinase-beta19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042870.2 RefSeqGene

      Range
      5000..12503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272101.2NP_001259030.1  matrix metalloproteinase-19 isoform 3 preproprotein

      See identical proteins and their annotated locations for NP_001259030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1, one of which results in a frameshift. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC023055
      Consensus CDS
      CCDS61146.1
      UniProtKB/Swiss-Prot
      Q99542
      Related
      ENSP00000386625.3, ENST00000409200.7
      Conserved Domains (3) summary
      pfam00413
      Location:103174
      Peptidase_M10; Matrixin
      pfam01471
      Location:3180
      PG_binding_1; Putative peptidoglycan binding domain
      cl00064
      Location:103174
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    2. NM_001414375.1NP_001401304.1  matrix metalloproteinase-19 isoform 4 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC023055
      UniProtKB/TrEMBL
      F8W1C3
    3. NM_002429.6NP_002420.1  matrix metalloproteinase-19 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_002420.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1, also known as rasi-1).
      Source sequence(s)
      AC023055
      Consensus CDS
      CCDS8895.1
      UniProtKB/Swiss-Prot
      B4E030, O15278, O95606, Q99542, Q99580
      UniProtKB/TrEMBL
      F8W1C3
      Related
      ENSP00000313437.4, ENST00000322569.9
      Conserved Domains (3) summary
      cd00094
      Location:286472
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:103256
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam01471
      Location:3180
      PG_binding_1; Putative peptidoglycan binding domain

    RNA

    1. NR_073606.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate splice sites at internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC023055
    2. NR_182299.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC023055

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      55835433..55842936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428863.1XP_047284819.1  matrix metalloproteinase-19 isoform X1

      UniProtKB/TrEMBL
      F8W1C3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      55802080..55809587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372076.1XP_054228051.1  matrix metalloproteinase-19 isoform X1

      UniProtKB/TrEMBL
      F8W1C3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001032360.1: Suppressed sequence

      Description
      NM_001032360.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_022790.1: Suppressed sequence

      Description
      NM_022790.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    3. NM_022792.2: Suppressed sequence

      Description
      NM_022792.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.