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    CG1416 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1416provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032961
    Locus tag
    Dmel_CG1416
    See related
    AllianceGenome:FB:FBgn0032961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aha1; Dmel\CG1416
    Summary
    Predicted to enable ATPase activator activity. Predicted to be involved in protein folding. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; head epidermis primordium; and visceral mesoderm derivative. Orthologous to several human genes including AHSA1 (activator of HSP90 ATPase activity 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1416 in Genome Data Viewer
    Location:
    40A2-40A2; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21758010..21761000)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21758010..21761000)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene no long nerve cord Neighboring gene steppke Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44269

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hsp90 Mediates Membrane Deformation and Exosome Release. Lauwers E, et al. Mol Cell, 2018 Sep 6. PMID 30193096
    2. Drosophila Morgana is an Hsp90-interacting protein with a direct role in microtubule polymerisation. Palumbo V, et al. J Cell Sci, 2020 Jan 23. PMID 31907206, Free PMC Article
    3. Socially-responsive gene expression in male Drosophila melanogaster is influenced by the sex of the interacting partner. Ellis LL, et al. Genetics, 2011 Jan. PMID 20980240, Free PMC Article
    4. Genomic analysis of heat-shock factor targets in Drosophila. Birch-Machin I, et al. Genome Biol, 2005. PMID 15998452, Free PMC Article
    5. RNAi-Mediated Reverse Genetic Screen Identified Drosophila Chaperones Regulating Eye and Neuromuscular Junction Morphology. Raut S, et al. G3 (Bethesda), 2017 Jul 5. PMID 28500055, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1416-PA
    CG1416-PB
    CG1416-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21758010..21761000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136277.3 → NP_610121.2  uncharacterized protein Dmel_CG1416, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610121.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9Q4
      Related
      FBpp0085258
      Conserved Domains (3) summary
      cd08892
      Location:221 → 346
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      COG5580
      Location:19 → 347
      COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]
      pfam09229
      Location:30 → 159
      Aha1_N; Activator of Hsp90 ATPase, N-terminal

    2. NM_165398.2 → NP_724361.1  uncharacterized protein Dmel_CG1416, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9Q4
      Related
      FBpp0085259
      Conserved Domains (3) summary
      cd08892
      Location:221 → 346
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      COG5580
      Location:19 → 347
      COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]
      pfam09229
      Location:30 → 159
      Aha1_N; Activator of Hsp90 ATPase, N-terminal

    3. NM_165399.2 → NP_724362.1  uncharacterized protein Dmel_CG1416, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9Q4
      Related
      FBpp0085260
      Conserved Domains (3) summary
      cd08892
      Location:221 → 346
      SRPBCC_Aha1; Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins
      COG5580
      Location:19 → 347
      COG5580; Activator of HSP90 ATPase [Posttranslational modification, protein turnover, chaperones]
      pfam09229
      Location:30 → 159
      Aha1_N; Activator of Hsp90 ATPase, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9Q4 Q9V9Q4

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