mat1a methionine adenosyltransferase 1A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mat1aprovided by ZNC
Official Full Name: methionine adenosyltransferase 1Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6127
See related: Ensembl:ENSDARG00000039605 AllianceGenome:ZFIN:ZDB-GENE-030131-6127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55442; wu:fi35e01
Summary: Predicted to enable methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to act upstream of or within one-carbon metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including anterior neural tube; lens; liver; optic cup; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (18628907..18637151, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (18497915..18506159, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW175386 (e-PCR)
- UniSTS:205775

fi35e01.x1 (e-PCR)
- UniSTS:197369

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S-adenosylmethionine synthase isoform type-1

Names: methionine adenosyltransferase I, alpha

NP_956165.1

EC 2.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199871.1 → NP_956165.1 S-adenosylmethionine synthase isoform type-1

See identical proteins and their annotated locations for NP_956165.1

Status: PROVISIONAL

Source sequence(s)

BC045343

UniProtKB/TrEMBL

A0A0R4IXB6, A0A8N7XJ85, B2GPU4, Q7ZW04

Related

ENSDARP00000057868.3, ENSDART00000057869.4

Conserved Domains (4) summary

PTZ00104
Location:11 → 389

PTZ00104; S-adenosylmethionine synthase; Provisional

pfam00438
Location:12 → 109

S-AdoMet_synt_N; S-adenosylmethionine synthetase, N-terminal domain

pfam02772
Location:124 → 245

S-AdoMet_synt_M; S-adenosylmethionine synthetase, central domain

pfam02773
Location:247 → 383

S-AdoMet_synt_C; S-adenosylmethionine synthetase, C-terminal domain