chp2 calcineurin-like EF-hand protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chp2provided by ZNC
Official Full Name: calcineurin-like EF-hand protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5810
See related: Ensembl:ENSDARG00000025788 AllianceGenome:ZFIN:ZDB-GENE-030131-5810
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55363; wu:fi19e07
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade. Predicted to act upstream of or within protein transport. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Orthologous to human CHP2 (calcineurin like EF-hand protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (20406143..20412288, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (20470411..20476556, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW153339 (e-PCR)
- UniSTS:205949

fa01g05.s1 (e-PCR)
- UniSTS:202133

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcineurin B homologous protein 2

Names: calcium binding protein P22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199836.2 → NP_956130.1 calcineurin B homologous protein 2

See identical proteins and their annotated locations for NP_956130.1

Status: PROVISIONAL

Source sequence(s)

BC044149

UniProtKB/TrEMBL

B2GNF7, F6PC25, Q803Y0

Related

ENSDARP00000008534.7, ENSDART00000008589.8

Conserved Domains (2) summary

COG5126
Location:17 → 178

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:114 → 178

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...