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    AP-1gamma Adaptor Protein complex 1, gamma subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AP-1gammaprovided by FlyBase
    Official Full Name
    Adaptor Protein complex 1, gamma subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030089
    Locus tag
    Dmel_CG9113
    See related
    AllianceGenome:FB:FBgn0030089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ap-1; AP-1; AP-1 gamma; AP-1g; AP-1[gamma]; AP1gamma; AP1gamma1; apl4; cg9113; CG9113; dgamma; Dmel\CG9113; gamma; gamma-Ada
    Summary
    Predicted to enable clathrin adaptor activity. Involved in clathrin-coated vesicle cargo loading; compound eye development; and secretory granule organization. Located in cytoplasmic vesicle and trans-Golgi network. Part of AP-1 adaptor complex. Is expressed in adult head; seminal vesicle; spermatid; spermatocyte; and spermatogonium. Orthologous to several human genes including AP1G1 (adaptor related protein complex 1 subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AP-1gamma in Genome Data Viewer
    Location:
    8C9-8C10; 1-26 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9108691..9117744)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9002724..9011777)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Bx42 Neighboring gene ADP-ribosylation factor related protein 1 Neighboring gene long non-coding RNA:CR45539 Neighboring gene forked end

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multifaceted control of E-cadherin dynamics by Adaptor Protein Complex 1 during epithelial morphogenesis. Moreno MR, et al. Mol Biol Cell, 2022 Aug 1. PMID 35609212, Free PMC Article
    2. Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor. Cotton M, et al. Curr Biol, 2013 Apr 8. PMID 23523246
    3. The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila. Szul T, et al. Cell Logist, 2011 Mar. PMID 21686256, Free PMC Article
    4. A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis. Hirst J, et al. BMC Cell Biol, 2011 May 20. PMID 21599933, Free PMC Article
    5. Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. Giagtzoglou N, et al. J Cell Sci, 2013 Aug 15. PMID 23788431, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we applied motif discovery to search for candidate transcription factors that could bind these regions and identified AP-1 and Stat92E as key regulators.
      Title: Discovery of transcription factors and regulatory regions driving in vivo tumor development by ATAC-seq and FAIRE-seq open chromatin profiling.
    2. AP-1-depleted photoreceptor neurons showed an intracellular accumulation of a Notch regulator, Scabrous, and downregulation of Notch by promoting its degradation in the lysosomes.
      Title: AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin adaptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-coated vesicle cargo loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of AP-1 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of AP-1 adaptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of AP-1 adaptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adaptor protein complex 1, gamma subunit
    Names
    AP-1gamma-PA
    AP-1gamma-PB
    AP-1gamma-PC
    AP-1gamma-PD
    AP-1gamma-PE
    AP-1gamma-PF
    AP-1gamma-PG
    AP-1gamma-PH
    AP-1gamma-PI
    CG9113-PA
    CG9113-PB
    CG9113-PC
    CG9113-PD
    CG9113-PE
    CG9113-PF
    CG9113-PG
    CG9113-PH
    CG9113-PI
    gamma subunit of AP-1 clathrin
    gamma-adaptin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9108691..9117744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176718.4 → NP_788891.2  adaptor protein complex 1, gamma subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788891.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q7KVR8
      Related
      FBpp0071232
      Conserved Domains (2) summary
      smart00809
      Location:869 → 972
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:68 → 624
      Adaptin_N; Adaptin N terminal region

    2. NM_167178.5 → NP_727311.2  adaptor protein complex 1, gamma subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727311.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q7KVR7
      Related
      FBpp0071230
      Conserved Domains (2) summary
      smart00809
      Location:863 → 966
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:68 → 618
      Adaptin_N; Adaptin N terminal region

    3. NM_001258661.2 → NP_001245590.1  adaptor protein complex 1, gamma subunit, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q86B59
      Conserved Domains (2) summary
      smart00809
      Location:856 → 959
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:55 → 611
      Adaptin_N; Adaptin N terminal region

    4. NM_001272442.1 → NP_001259371.1  adaptor protein complex 1, gamma subunit, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q9W388
      Conserved Domains (2) summary
      smart00809
      Location:850 → 953
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:55 → 605
      Adaptin_N; Adaptin N terminal region

    5. NM_001103448.3 → NP_001096918.1  adaptor protein complex 1, gamma subunit, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q9W388
      Conserved Domains (2) summary
      smart00809
      Location:850 → 953
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:55 → 605
      Adaptin_N; Adaptin N terminal region

    6. NM_176717.4 → NP_788890.2  adaptor protein complex 1, gamma subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788890.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q86B59
      Related
      FBpp0071233
      Conserved Domains (2) summary
      smart00809
      Location:856 → 959
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:55 → 611
      Adaptin_N; Adaptin N terminal region

    7. NM_132299.6 → NP_572527.2  adaptor protein complex 1, gamma subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572527.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q9W388
      Related
      FBpp0071231
      Conserved Domains (2) summary
      smart00809
      Location:850 → 953
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:55 → 605
      Adaptin_N; Adaptin N terminal region

    8. NM_206671.4 → NP_996394.2  adaptor protein complex 1, gamma subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996394.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q9W388
      Conserved Domains (2) summary
      smart00809
      Location:850 → 953
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:55 → 605
      Adaptin_N; Adaptin N terminal region

    9. NM_001258660.1 → NP_001245589.1  adaptor protein complex 1, gamma subunit, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q494L9, Q9W388
      Conserved Domains (2) summary
      smart00809
      Location:850 → 953
      Alpha_adaptinC2; Adaptin C-terminal domain
      pfam01602
      Location:55 → 605
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVR7 Q7KVR7
    Q7KVR8 Q7KVR8
    Q86B59 Q86B59
    Q9W388 Q9W388

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