esr2a estrogen receptor 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: esr2aprovided by ZNC
Official Full Name: estrogen receptor 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030116-2
See related: Ensembl:ENSDARG00000016454 AllianceGenome:ZFIN:ZDB-GENE-030116-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ER[b]2; ER[b]a; abrrl5; zfER[b]2; zfER-beta2
Summary: Enables estradiol binding activity; nuclear estrogen receptor activity; and steroid hormone binding activity. Acts upstream of or within several processes, including regulation of transcription by RNA polymerase II; response to estrogen; and steroid hormone receptor signaling pathway. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including blastodisc; brain; pelvic fin bud; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (21583537..21635659)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (21695571..21735986)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
Title: Functional Analysis of Nuclear Estrogen Receptors in Zebrafish Reproduction by Genome Editing Approach.
Data suggest that endocrine disruptor, 17alpha-ethinylestradiol, disrupts primordial germ cell migration and distribution in embryonic zebrafish; this effect appears to be mediated through estrogen receptor Esr2a (not Esr1 or Esr2b).
Title: Use of antagonists and morpholinos in loss-of-function analyses: estrogen receptor ESR2a mediates the effects of 17alpha-ethinylestradiol on primordial germ cell distribution in zebrafish.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
Title: Morpholino-mediated knockdown of ERα, ERβa, and ERβb mRNAs in zebrafish (Danio rerio) embryos reveals differential regulation of estrogen-inducible genes.
Report stable reporter gene assays based on stable expression of subtypes of zebrafish ER (zfERalpha, zfERbeta1, and zfERbeta2) coupled to estrogen response element-driven luciferase in a zebrafish liver cell line.
Title: Selective activation of zebrafish estrogen receptor subtypes by chemicals by using stable reporter gene assay developed in a zebrafish liver cell line.
Involvement of maternal esr2a mRNA, presumably transactivated by maternal 17beta-estradiol stored in the oocyte from enveloping granulosa cells, in the epigenetic programming of zebrafish development.
Title: The knockdown of the maternal estrogen receptor 2a (esr2a) mRNA affects embryo transcript contents and larval development in zebrafish.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta after a 21-day exposure to endocrine-disrupting chemicals.
Title: Temperature and photoperiod affect the endocrine disruption effects of ethinylestradiol, nonylphenol and their binary mixture in zebrafish (Danio rerio).
genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A and ERbeta-B and induces apoptosis in an ER-independent manner
Title: The phytoestrogen genistein affects zebrafish development through two different pathways.
We conclude that signaling via ERbeta(2) is essential for hair cell development and may involve an interaction with the Notch signaling pathway during cell fate decision in the neuromast maturation process.
Title: Estrogen receptor subtype beta2 is involved in neuromast development in zebrafish (Danio rerio) larvae.
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
Title: Analysis of the estrogen regulation of the zebrafish estrogen receptor (ER) reveals distinct effects of ERalpha, ERbeta1 and ERbeta2.
Induction of apolipoprotein Eb (apoeb) and up-regulation of estrogen receptor 2a (esr2a) transcripts were observed in the epidermis at initiator sites of zebrafish ectodermal/dermal appendage morphogenesis.
Title: Epidermal transient down-regulation of retinol-binding protein 4 and mirror expression of apolipoprotein Eb and estrogen receptor 2a during zebrafish fin and scale development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables estradiol binding	IDA Inferred from Direct Assay more info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables steroid binding	IEA Inferred from Electronic Annotation more info
enables steroid hormone binding	IDA Inferred from Direct Assay more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to estrogen	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: estrogen receptor 2a

Names: ERbeta-B; NR3A2-B; estrogen receptor beta2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_180966.2 → NP_851297.1 estrogen receptor 2a

See identical proteins and their annotated locations for NP_851297.1

Status: PROVISIONAL

Source sequence(s)

BC044349

UniProtKB/TrEMBL

B2GS75, F6NRA7, Q7ZU32

Related

ENSDARP00000017514.5, ENSDART00000010643.7

Conserved Domains (3) summary

cd06949
Location:280 → 517

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:154 → 233

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam12497
Location:31 → 134

ERbeta_N; Estrogen receptor beta