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    Gpr180 G protein-coupled receptor 180 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr180provided by RGD
    Official Full Name
    G protein-coupled receptor 180provided by RGD
    Primary source
    RGD:1359193
    See related
    EnsemblRapid:ENSRNOG00000009766 AllianceGenome:RGD:1359193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. Orthologous to human GPR180 (G protein-coupled receptor 180). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 56.6), Brain (RPKM 56.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr180 in Genome Data Viewer
    Location:
    15q24
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (101602870..101635556)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (95195782..95224955)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (103340387..103369633)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548945 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 5 Neighboring gene TDP-glucose 4,6-dehydratase Neighboring gene uncharacterized LOC134482020 Neighboring gene SRY-box transcription factor 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of experimental intimal thickening in mice lacking a novel G-protein-coupled receptor. Tsukada S, et al. Circulation, 2003 Jan 21. PMID 12538434
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94555

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane protein GPR180
    Names
    intimal thickness-related receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006994.2 → NP_001006995.1  integral membrane protein GPR180 isoform 1

      See identical proteins and their annotated locations for NP_001006995.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A096MKB1, G3V799, Q5XIJ2
      Conserved Domains (1) summary
      pfam10192
      Location:42 → 304
      GpcrRhopsn4; Rhodopsin-like GPCR transmembrane domain

    2. NM_001415002.1 → NP_001401931.1  integral membrane protein GPR180 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HUG1
      Related
      ENSRNOP00000013329.5, ENSRNOT00000013329.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      101602870..101635556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599719.3 → XP_017455208.1  integral membrane protein GPR180 isoform X2

      Related
      ENSRNOP00000101898.1, ENSRNOT00000149070.1

    2. XM_063274349.1 → XP_063130419.1  integral membrane protein GPR180 isoform X1

      Related
      ENSRNOP00000068447.3, ENSRNOT00000077047.4

    3. XM_063274351.1 → XP_063130421.1  integral membrane protein GPR180 isoform X5

    4. XM_063274350.1 → XP_063130420.1  integral membrane protein GPR180 isoform X4

    5. XM_006252455.5 → XP_006252517.1  integral membrane protein GPR180 isoform X3

      Conserved Domains (1) summary
      cl21735
      Location:169 → 329
      Lung_7-TM_R; Lung seven transmembrane receptor

    6. XM_063274352.1 → XP_063130422.1  integral membrane protein GPR180 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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