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    S100a5 S100 calcium binding protein A5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295211, updated on 9-Dec-2024

    Summary

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    Official Symbol
    S100a5provided by RGD
    Official Full Name
    S100 calcium binding protein A5provided by RGD
    Primary source
    RGD:1308996
    See related
    EnsemblRapid:ENSRNOG00000011748 AllianceGenome:RGD:1308996
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium-dependent protein binding activity; metal ion binding activity; and protein homodimerization activity. Predicted to be located in neuronal cell body. Predicted to be active in nucleus. Orthologous to human S100A5 (S100 calcium binding protein A5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 24.5), Brain (RPKM 12.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See S100a5 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178392922..178397128)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (176095332..176099546)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189999669..190005877)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A3 Neighboring gene S100 calcium binding protein A2 Neighboring gene S100 calcium-binding protein A4 Neighboring gene S100 calcium binding protein A6 Neighboring gene S100 calcium binding protein A7A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Solution structure and dynamics of S100A5 in the apo and Ca2+-bound states. Bertini I, et al. J Biol Inorg Chem, 2009 Sep. PMID 19536568
    2. Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily. Schäfer BW, et al. J Biol Chem, 2000 Sep 29. PMID 10882717
    3. Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Tadenev AL, et al. Proc Natl Acad Sci U S A, 2011 Jun 21. PMID 21646512, Free PMC Article
    4. S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells. Hsieh HL, et al. J Cell Sci, 2002 Aug 1. PMID 12118070
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein S100-A5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106438.1 → NP_001099908.1  protein S100-A5

      See identical proteins and their annotated locations for NP_001099908.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/Swiss-Prot
      P63083
      UniProtKB/TrEMBL
      A6J6P8
      Related
      ENSRNOP00000015712.4, ENSRNOT00000015712.8
      Conserved Domains (1) summary
      cd00213
      Location:3 → 88
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      178392922..178397128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232601.5 → XP_006232663.1  protein S100-A5 isoform X1

      See identical proteins and their annotated locations for XP_006232663.1

      UniProtKB/Swiss-Prot
      P63083
      UniProtKB/TrEMBL
      A6J6P8
      Conserved Domains (1) summary
      cd00213
      Location:3 → 88
      S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...

    2. XM_063281598.1 → XP_063137668.1  protein S100-A5 isoform X1

      UniProtKB/Swiss-Prot
      P63083
      UniProtKB/TrEMBL
      A6J6P8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63083.1 GenPept UniProtKB/Swiss-Prot:P63083

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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