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    Cts7l2 cathepsin 7 like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290981, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Cts7l2provided by RGD
    Official Full Name
    cathepsin 7 like 2provided by RGD
    Primary source
    RGD:1308751
    See related
    EnsemblRapid:ENSRNOG00000039954 AllianceGenome:RGD:1308751
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308751
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See Cts7l2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (3909208..3912241)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (3903602..3907088)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (4270207..4273173)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene thioredoxin-related transmembrane protein 3, pseudogene 1 Neighboring gene testin gene Neighboring gene cathepsin L-like 3 Neighboring gene death associated protein kinase 1 Neighboring gene uncharacterized LOC100912124 Neighboring gene uncharacterized LOC103694025

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    procathepsin L
    Names
    cathepsin L1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      3909208..3912241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_225137.7 → XP_225137.5  procathepsin L

      See identical proteins and their annotated locations for XP_225137.5

      UniProtKB/TrEMBL
      A6KAF5, D3ZKC3
      Related
      ENSRNOP00000074913.1, ENSRNOT00000090013.3
      Conserved Domains (2) summary
      smart00848
      Location:29 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:114 → 329
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version

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