Nufip1 nuclear FMR1 interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nufip1provided by MGI
Official Full Name: nuclear FMR1 interacting protein 1provided by MGI
Primary source: MGI:MGI:1351474
See related: Ensembl:ENSMUSG00000022009 AllianceGenome:MGI:1351474
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nufip
Summary: Enables RNA binding activity. Predicted to be involved in box C/D snoRNP assembly and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is active in synapse. Is expressed in early conceptus; inner cell mass; oocyte; and trophectoderm. Orthologous to human NUFIP1 (nuclear FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 3.7), adrenal adult (RPKM 3.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 40.35 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (76348337..76372527)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (76110891..76137379)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables snoRNA binding	IEA Inferred from Electronic Annotation more info
contributes_to snoRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in box C/D snoRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in box C/D snoRNP assembly	IEA Inferred from Electronic Annotation more info
involved_in box C/D snoRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perichromatin fibrils	ISO Inferred from Sequence Orthology more info
located_in perichromatin fibrils	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of pre-snoRNP complex	IEA Inferred from Electronic Annotation more info
part_of pre-snoRNP complex	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IEP Inferred from Expression Pattern more info	PubMed
part_of transcription elongation factor complex	ISO Inferred from Sequence Orthology more info
part_of transcription elongation factor complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: FMR1-interacting protein NUFIP1

Names: nuclear FMRP-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424636.1 → NP_001411565.1 FMR1-interacting protein NUFIP1 isoform 2

Status: VALIDATED

Source sequence(s)

AC125128
NM_013745.6 → NP_038773.1 FMR1-interacting protein NUFIP1 isoform 1

See identical proteins and their annotated locations for NP_038773.1

Status: VALIDATED

Source sequence(s)

AC125128

Consensus CDS

CCDS27284.1

UniProtKB/Swiss-Prot

Q9CV69, Q9QXX8

Related

ENSMUSP00000022586.2, ENSMUST00000022586.2

Conserved Domains (1) summary

pfam10453
Location:207 → 259

NUFIP1; Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)