Tert telomerase reverse transcriptase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tertprovided by MGI
Official Full Name: telomerase reverse transcriptaseprovided by MGI
Primary source: MGI:MGI:1202709
See related: Ensembl:ENSMUSG00000021611 AllianceGenome:MGI:1202709
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TR; TP2; TRT; EST2; TCS1
Summary: Enables telomerase RNA binding activity; telomerase activity; and transcription coactivator binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of hair cycle; and positive regulation of stem cell proliferation. Acts upstream of or within positive regulation of D-glucose import. Located in mitochondrion and plasma membrane. Part of telomerase catalytic core complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; sensory organ; and skin. Used to study prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; carcinoma (multiple); gastrointestinal stromal tumor; leukemia (multiple); and melanoma (multiple). Orthologous to human TERT (telomerase reverse transcriptase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 4.7), adrenal adult (RPKM 3.6) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.12 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (73775030..73797962)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (73626911..73649843)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential.
Title: TERT upregulation promotes cell proliferation via degradation of p21 and increases carcinogenic potential.
TERT activation targets DNA methylation and multiple aging hallmarks.
Title: TERT activation targets DNA methylation and multiple aging hallmarks.
An association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells.
Title: An association between elevated telomerase reverse transcriptase expression and the immune tolerance disruption of dendritic cells.
TERT mediates the U-shape of glucocorticoids effects in modulation of hippocampal neural stem cells and associated brain function.
Title: TERT mediates the U-shape of glucocorticoids effects in modulation of hippocampal neural stem cells and associated brain function.
Telomere dysfunction in Tert knockout mice delays Braf[V600E] -induced melanoma development.
Title: Telomere dysfunction in Tert knockout mice delays Braf(V600E) -induced melanoma development.
The Wnt/beta-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study.
Title: The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study.
Prenatal stress modulates HPA axis homeostasis of offspring through dentate TERT independently of glucocorticoids receptor.
Title: Prenatal stress modulates HPA axis homeostasis of offspring through dentate TERT independently of glucocorticoids receptor.
PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis.
Title: PinX1 Depletion Improves Liver Injury in a Mouse Model of Nonalcoholic Fatty Liver Disease via Increasing Telomerase Activity and Inhibiting Apoptosis.
Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice.
Title: Pulmonary Alveolar Stem Cell Senescence, Apoptosis, and Differentiation by p53-Dependent and -Independent Mechanisms in Telomerase-Deficient Mice.
Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function.
Title: Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function.

Submit: New GeneRIF Correction See all GeneRIFs (141)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC27918P1 (e-PCR)
- UniSTS:272391

PMC27918P2 (e-PCR)
- UniSTS:272392

Tert (e-PCR), detects polymorphism
- UniSTS:165013

Tert (e-PCR), detects polymorphism
- UniSTS:536555

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA-dependent RNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables RNA-dependent RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables RNA-directed DNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables telomerase RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomerase RNA binding	ISO Inferred from Sequence Orthology more info
enables telomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables telomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables telomerase activity	ISO Inferred from Sequence Orthology more info
enables telomerase activity	TAS Traceable Author Statement more info	PubMed
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables template-free RNA nucleotidyltransferase	IEA Inferred from Electronic Annotation more info
enables template-free RNA nucleotidyltransferase	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in DNA strand elongation	IEA Inferred from Electronic Annotation more info
involved_in DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in RNA-templated DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in RNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to telomere	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular senescence	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hair cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleolus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transdifferentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transdifferentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	IEA Inferred from Electronic Annotation more info
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEA Inferred from Electronic Annotation more info
involved_in siRNA processing	ISO Inferred from Sequence Orthology more info
involved_in siRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in siRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in siRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via recombination	NAS Non-traceable Author Statement more info	PubMed
involved_in telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	ISS Inferred from Sequence or Structural Similarity more info
involved_in telomere maintenance via telomerase	NAS Non-traceable Author Statement more info	PubMed
involved_in telomere maintenance via telomerase	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
colocalizes_with PML body	ISO Inferred from Sequence Orthology more info
part_of RNA-directed RNA polymerase complex	ISO Inferred from Sequence Orthology more info
part_of TERT-RMRP complex	ISO Inferred from Sequence Orthology more info
part_of TERT-RMRP complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of telomerase catalytic core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of telomerase catalytic core complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of telomerase catalytic core complex	ISO Inferred from Sequence Orthology more info
part_of telomerase catalytic core complex	NAS Non-traceable Author Statement more info	PubMed
part_of telomerase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of telomerase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info
part_of telomerase holoenzyme complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: telomerase reverse transcriptase

Names: telomerase catalytic subunit; telomerase reverse transcriptase beta

NP_001349316.1

EC 2.7.7.49

NP_001349317.1

EC 2.7.7.49

NP_033380.1

EC 2.7.7.49

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362387.1 → NP_001349316.1 telomerase reverse transcriptase isoform 2

Status: VALIDATED

Source sequence(s)

AC158359, AK133783, BC082327

Conserved Domains (2) summary

smart00975
Location:57 → 191

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain

cd01648
Location:422 → 536

TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...
NM_001362388.1 → NP_001349317.1 telomerase reverse transcriptase isoform 3

Status: VALIDATED

Source sequence(s)

AK133783, BC082327, BC127068

UniProtKB/TrEMBL

A0JNY9

Conserved Domains (2) summary

cd01648
Location:277 → 391

TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...

cl13446
Location:1 → 46

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain
NM_009354.2 → NP_033380.1 telomerase reverse transcriptase isoform 1

See identical proteins and their annotated locations for NP_033380.1

Status: VALIDATED

Source sequence(s)

AF051911, AK133783, BC082327

Consensus CDS

CCDS26633.1

UniProtKB/Swiss-Prot

O35432, O70372, Q9JK99

Related

ENSMUSP00000022104.8, ENSMUST00000022104.9

Conserved Domains (2) summary

smart00975
Location:450 → 584

Telomerase_RBD; Telomerase ribonucleoprotein complex - RNA binding domain

cd01648
Location:815 → 929

TERT; TERT: Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as ...