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    dnc-5 Dynactin subunit 5 [ Caenorhabditis elegans ]

    Gene ID: 171856, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnc-5
    Official Full Name
    Dynactin subunit 5
    Primary source
    WormBase:WBGene00022118
    Locus tag
    CELE_Y71F9AL.14
    See related
    AllianceGenome:WB:WBGene00022118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Part of dynactin complex. Is expressed in nervous system. Orthologous to human DCTN5 (dynactin subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnc-5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (2880876..2883454, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CUE domain-containing protein Neighboring gene Myb_DNA-bind_3 domain-containing protein Neighboring gene Actin-related protein 3 Neighboring gene Ovule protein Neighboring gene pre-microRNA mir-5546

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights on UNC-104-dynein/dynactin interactions and their implications on axonal transport in Caenorhabditis elegans. Chen CW, et al. J Neurosci Res, 2019 Feb. PMID 30311677
    2. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Terasawa M, et al. Genes Cells, 2010 Nov. PMID 20964796, Free PMC Article
    3. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dynactin subunit 5
    NP_001380049.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2880876..2883454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393141.1 → NP_001380049.1  Dynactin subunit 5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4I1
      Conserved Domains (1) summary
      cd03359
      Location:13 → 173
      LbH_Dynactin_5; Dynactin 5 (or subunit p25); Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
    Nucleotide Protein
    Heading Accession and Version

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