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    Ambp alpha 1 microglobulin/bikunin precursor [ Mus musculus (house mouse) ]

    Gene ID: 11699, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ambpprovided by MGI
    Official Full Name
    alpha 1 microglobulin/bikunin precursorprovided by MGI
    Primary source
    MGI:MGI:88002
    See related
    Ensembl:ENSMUSG00000028356 AllianceGenome:MGI:88002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UTI; ASPI; Itil; HI-30; Intin4
    Summary
    This gene encodes a fusion protein that undergoes proteolytic processing to generate two mature proteins: alpha-1-microglobulin (A1m) is a heme-binding plasma glycoprotein of the lipocalin superfamily of proteins that bind to hydrophobic molecules, whereas bikunin belongs to the superfamily of Kunitz-type protease inhibitors. The transgenic mice specifically lacking bikunin, but not A1m, exhibit female infertility and an increased sensitivity to lung metastasis. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in liver E18 (RPKM 1051.1), liver adult (RPKM 770.6) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Ambp in Genome Data Viewer
    Location:
    4 B3; 4 33.96 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63061512..63072409, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63143275..63154172, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25391 Neighboring gene zinc finger protein 618 Neighboring gene predicted gene, 30764 Neighboring gene kinesin family member 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62883492-62883675 Neighboring gene collagen, type XXVII, alpha 1 Neighboring gene microRNA 455

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables IgA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables antioxidant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables antioxidant activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chondroitin sulfate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chondroitin sulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables collagen fibril binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen fibril binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular oxidant detoxification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytochrome c metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytochrome c metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hemoglobin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hemoglobin metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein maturation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in matrix side of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein AMBP
    Names
    Urinary Trypsin Inhibitor
    ulinastatin
    NP_031469.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007443.5NP_031469.1  protein AMBP preproprotein

      See identical proteins and their annotated locations for NP_031469.1

      Status: REVIEWED

      Source sequence(s)
      AL691496
      Consensus CDS
      CCDS18248.1
      UniProtKB/Swiss-Prot
      Q07456, Q61294, Q925W1, Q9DBJ9
      Related
      ENSMUSP00000030041.5, ENSMUST00000030041.5
      Conserved Domains (2) summary
      pfam00014
      Location:230281
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00061
      Location:41185
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63061512..63072409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)