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    Abhd4 abhydrolase domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 105501, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abhd4provided by MGI
    Official Full Name
    abhydrolase domain containing 4provided by MGI
    Primary source
    MGI:MGI:1915938
    See related
    Ensembl:ENSMUSG00000040997 AllianceGenome:MGI:1915938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abh4; 1110035H23Rik
    Summary
    Enables lysophospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Acts upstream of or within N-acylethanolamine metabolic process. Predicted to be active in lipid droplet and mitochondrion. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; and retina. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 181.0), testis adult (RPKM 84.5) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Abhd4 in Genome Data Viewer
    Location:
    14 C2; 14 27.71 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54491586..54506626)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54254129..54269169)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha chain Neighboring gene STARR-positive B cell enhancer ABC_E7311 Neighboring gene CapStarr-seq enhancers MGSCv37_chr14:54846812-54847013 and MGSCv37_chr14:54847102-54847395 Neighboring gene STARR-positive B cell enhancer ABC_E5435 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:54852981-54853251 Neighboring gene STARR-positive B cell enhancer ABC_E1168 Neighboring gene predicted gene 43305 Neighboring gene T cell receptor alpha constant Neighboring gene olfactory receptor family 6 subfamily E member 1 Neighboring gene defender against cell death 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice. Seramur ME, et al. J Lipid Res, 2023 Aug. PMID 37352974, Free PMC Article
    2. ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Lee HC, et al. Biochemistry, 2015 Apr 21. PMID 25853435, Free PMC Article
    3. ABHD4-dependent developmental anoikis safeguards the embryonic brain. László ZI, et al. Nat Commun, 2020 Aug 31. PMID 32868797, Free PMC Article
    4. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. Simon GM, et al. J Biol Chem, 2006 Sep 8. PMID 16818490
    5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice.
      Title: ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice.
    2. These findings, taken together, designate ABHD4 as a principal regulator of N-acyl phospholipid metabolism in the mammalian nervous system.
      Title: ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system.
    3. Lysophospholipase/phospholipase B (EC 3.1.1.5) specific for N-acyl phosphatidylethanolamine (NAPE) suggesting a role in the biosynthesis of N-acyl ethanolamines including the endocannabinoid anandamide.
      Title: Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-acylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in N-acylphosphatidylethanolamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    (Lyso)-N-acylphosphatidylethanolamine lipase
    Names
    abhydrolase domain-containing protein 4
    alpha/beta hydrolase domain-containing protein 4
    alpha/beta-hydrolase 4
    lyso-N-acylphosphatidylethanolamine lipase
    protein ABHD4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205181.1 → NP_001192110.1  (Lyso)-N-acylphosphatidylethanolamine lipase isoform 2

      See identical proteins and their annotated locations for NP_001192110.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK030250, AK049366, CN713874, CT573018
      Consensus CDS
      CCDS56955.1
      UniProtKB/TrEMBL
      Q3U7M5, Q8C0M2
      Related
      ENSMUSP00000137214.2, ENSMUST00000180359.8
      Conserved Domains (1) summary
      PLN02894
      Location:32 → 314
      PLN02894; hydrolase, alpha/beta fold family protein

    2. NM_134076.3 → NP_598837.3  (Lyso)-N-acylphosphatidylethanolamine lipase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      CT573018
      Consensus CDS
      CCDS56954.1
      UniProtKB/Swiss-Prot
      Q8VD66
      UniProtKB/TrEMBL
      Q3U7M5
      Related
      ENSMUSP00000044134.9, ENSMUST00000041197.13
      Conserved Domains (1) summary
      PLN02894
      Location:11 → 338
      PLN02894; hydrolase, alpha/beta fold family protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54491586..54506626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518367.4 → XP_006518430.1  (Lyso)-N-acylphosphatidylethanolamine lipase isoform X1

      See identical proteins and their annotated locations for XP_006518430.1

      UniProtKB/TrEMBL
      Q3U7M5, Q8C0M2
      Conserved Domains (1) summary
      PLN02894
      Location:32 → 314
      PLN02894; hydrolase, alpha/beta fold family protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD66.1 GenPept UniProtKB/Swiss-Prot:Q8VD66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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