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    RING/FYVE/PHD zinc finger superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838600, updated on 18-Sep-2024

    Summary

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    Official Full Name
    RING/FYVE/PHD zinc finger superfamily protein
    Primary source
    TAIR:AT1G20110
    Locus tag
    AT1G20110
    See related
    Araport:AT1G20110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FYVE-domain protein 1; FYVE1; T20H2.10; T20H2_10
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (6971424..6975130)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RHO-related protein from plants 2 Neighboring gene DNA ligase-like protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant unique ESCRT component FREE1 regulates autophagosome closure. Zeng Y, et al. Nat Commun, 2023 Mar 30. PMID 36997511, Free PMC Article
    2. Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency. Zhang T, et al. Int J Mol Sci, 2021 Aug 16. PMID 34445480, Free PMC Article
    3. The plant ESCRT component FREE1 shuttles to the nucleus to attenuate abscisic acid signalling. Li H, et al. Nat Plants, 2019 May. PMID 30962512
    4. Functional Analysis of Plant FYVE Domain Proteins in Endosomal Trafficking. Shen W, et al. Methods Mol Biol, 2020. PMID 32632807
    5. RST1 Is a FREE1 Suppressor That Negatively Regulates Vacuolar Trafficking in Arabidopsis. Zhao Q, et al. Plant Cell, 2019 Sep. PMID 31221737, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The plant unique ESCRT component FREE1 regulates autophagosome closure.
      Title: The plant unique ESCRT component FREE1 regulates autophagosome closure.
    2. Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency.
      Title: Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency.
    3. SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling.
      Title: SINAT E3 Ubiquitin Ligases Mediate FREE1 and VPS23A Degradation to Modulate Abscisic Acid Signaling.
    4. Functional Analysis of Plant FYVE Domain Proteins in Endosomal Trafficking.
      Title: Functional Analysis of Plant FYVE Domain Proteins in Endosomal Trafficking.
    5. Analysis of Membrane Proteins Transport from Endosomal Compartments to Vacuoles.
      Title: Analysis of Membrane Proteins Transport from Endosomal Compartments to Vacuoles.
    6. The effect of ABRE BINDING FACTOR 4-mediated FYVE1 on salt stress tolerance in Arabidopsis.
      Title: The effect of ABRE BINDING FACTOR 4-mediated FYVE1 on salt stress tolerance in Arabidopsis.
    7. RST1 is a negative regulator controlling membrane protein homeostasis and FREE1-mediated functions in plants.
      Title: RST1 Is a FREE1 Suppressor That Negatively Regulates Vacuolar Trafficking in Arabidopsis.
    8. study demonstrates the crosstalk between endomembrane trafficking and ABA signalling at the transcriptional level and highlights the moonlighting properties of the plant ESCRT subunit FREE1, which has evolved unique non-endosomal functions in the nucleus besides its roles in membrane trafficking in the cytoplasm. [FREE1]
      Title: The plant ESCRT component FREE1 shuttles to the nucleus to attenuate abscisic acid signalling.
    9. FYVE1 is essential for plant growth and development and place FYVE1 as a key regulator of intracellular trafficking and vacuole biogenesis.
      Title: FYVE1 is essential for vacuole biogenesis and intracellular trafficking in Arabidopsis.
    10. FREE1 binds to phosphatidylinositol-3-phosphate (PI3P) and ubiquitin and specifically interacts with Vps23 via PTAP-like tetrapeptide motifs to be incorporated into the ESCRT-I complex.
      Title: A unique plant ESCRT component, FREE1, regulates multivesicular body protein sorting and plant growth.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101865.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intralumenal vesicle formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multivesicular body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cellular response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESCRT I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING/FYVE/PHD zinc finger superfamily protein
    NP_564103.1
    • RING/FYVE/PHD zinc finger superfamily protein; FUNCTIONS IN: phosphoinositide binding; INVOLVED IN: signal transduction; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, FYVE-type (InterPro:IPR000306), Zinc finger, FYVE-related (InterPro:IPR017455), Zinc finger, FYVE/PHD-type (InterPro:IPR011011); BEST Arabidopsis thaliana protein match is: phosphatidylinositol-4-phosphate 5-kinase family protein (TAIR:AT3G14270.1); Has 29282 Blast hits to 20083 proteins in 828 species: Archae - 11; Bacteria - 1932; Metazoa - 10999; Fungi - 6486; Plants - 4104; Viruses - 590; Other Eukaryotes - 5160 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6971424..6975130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101865.4 → NP_564103.1  RING/FYVE/PHD zinc finger superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940J6, Q9ASS2
      UniProtKB/TrEMBL
      A0A5S9V994, A0A654EBJ8
      Conserved Domains (2) summary
      smart00064
      Location:449 → 515
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      cd00934
      Location:297 → 363
      PTB; Phosphotyrosine-binding (PTB) PH-like fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ASS2.1

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