U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein Clusters

    • Showing Current items.

    SYN3 Rad21/Rec8-like family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825124, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SYN3
    Official Full Name
    Rad21/Rec8-like family protein
    Primary source
    TAIR:AT3G59550
    Locus tag
    AT3G59550
    See related
    Araport:AT3G59550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRAD21.2; ATSYN3; SISTER CHROMATID COHESION 1 PROTEIN 3
    Summary
    Encodes an alpha-kleisin protein that is localized primarily in the nucleolus and is essential for megagametogenesis and plays an important role in pollen development. alpha-kleisins are core components of meiotic and mitotic cohesin complexes.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SYN3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (21997052..22000737)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RHOMBOID-like protein 13 Neighboring gene Calcium-dependent phosphotriesterase superfamily protein Neighboring gene Ribosomal L38e protein family Neighboring gene Ypt/Rab-GAP domain of gyp1p superfamily protein Neighboring gene Plant regulator RWP-RK family protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression of epitope-tagged SYN3 cohesin proteins can disrupt meiosis in Arabidopsis. Yuan L, et al. J Genet Genomics, 2014 Mar 20. PMID 24656235
    2. The Arabidopsis cohesin protein SYN3 localizes to the nucleolus and is essential for gametogenesis. Jiang L, et al. Plant J, 2007 Jun. PMID 17488242
    3. The Arabidopsis SYN3 cohesin protein is important for early meiotic events. Yuan L, et al. Plant J, 2012 Jul. PMID 22381039
    4. Cloning and characterization of two Arabidopsis genes that belong to the RAD21/REC8 family of chromosome cohesin proteins. Dong F, et al. Gene, 2001 Jun 13. PMID 11410371
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SYN3 expression from 35S promoter with Myc or FAST tag causes a reduction in SYN1 mRNA levels and results in alterations in sister chromatid cohesion, homologous chromosome synapsis and synaptonemal complex formation during male and female meiosis.
      Title: Expression of epitope-tagged SYN3 cohesin proteins can disrupt meiosis in Arabidopsis.
    2. Downregulation of SYN3 results in defects in chromosome synapsis and condensation during male and female meiosis.
      Title: The Arabidopsis SYN3 cohesin protein is important for early meiotic events.
    3. localizes primarily in the nucleolus of both meiotic and mitotic cells, essential for megagametogenesis and plays an important role in pollen
      Title: The Arabidopsis cohesin protein SYN3 localizes to the nucleolus and is essential for gametogenesis.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    NM_115817.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within megagametogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cell cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cohesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Rad21/Rec8-like family protein
    NP_191514.1
    • SYN3; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: mitosis, megagametogenesis, pollen development; LOCATED IN: nucleolus, nucleus, nuclear cohesin complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Rad21/Rec8 like protein, C-terminal (InterPro:IPR006909), Rad21/Rec8 like protein, N-terminal (InterPro:IPR006910); BEST Arabidopsis thaliana protein match is: Zinc knuckle (CCHC-type) family protein (TAIR:AT4G05360.1); Has 1082 Blast hits to 944 proteins in 221 species: Archae - 0; Bacteria - 42; Metazoa - 397; Fungi - 305; Plants - 228; Viruses - 4; Other Eukaryotes - 106 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21997052..22000737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115817.3 → NP_191514.1  Rad21/Rec8-like family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191514.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FQ19, Q9M1B3
      UniProtKB/TrEMBL
      A0A5S9XMZ8, A0A654FJ92
      Conserved Domains (2) summary
      pfam04824
      Location:636 → 687
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1 → 104
      Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FQ19.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools