U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein Clusters

    • Showing Current items.

    MC8 metacaspase 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838212, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MC8
    Official Full Name
    metacaspase 8
    Primary source
    TAIR:AT1G16420
    Locus tag
    AT1G16420
    See related
    Araport:AT1G16420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA METACASPASE 8; ATMC8; AtMCP2e; F3O9.22; F3O9_22; MCP2e; metacaspase 2e; metacaspase 8
    Summary
    Encodes a metacaspase (cysteine-type endopeptidase) that is involved in promoting programmed cell death in response to hydrogen peroxide (H2O2), UV light, and methyl viologen (MV). Transcript levels rise in response to UV-C, H2O2, and MV. In vitro assays demonstrate that this enzyme has a preference for cleaving after an arginine residue, and it has a pH optimum of 8.0.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MC8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (5612150..5614020, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 79, subfamily F, polypeptide 2 Neighboring gene cytochrome p450 79f1 Neighboring gene Surfeit locus protein 5 subunit 22 of Mediator complex Neighboring gene root hair specific 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Metacaspase-8 modulates programmed cell death induced by ultraviolet light and H2O2 in Arabidopsis. He R, et al. J Biol Chem, 2008 Jan 11. PMID 17998208
    2. METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress. Bernacki MJ, et al. Int J Mol Sci, 2024 Mar 11. PMID 38542169, Free PMC Article
    3. Arabidopsis G-protein interactome reveals connections to cell wall carbohydrates and morphogenesis. Klopffleisch K, et al. Mol Syst Biol, 2011 Sep 27. PMID 21952135, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress.
      Title: METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress.
    2. metacaspase-8 is part of an evolutionary conserved programmed cell death(PCD) pathway activated by oxidative stress [metacaspase 8] [AtMC8]
      Title: Metacaspase-8 modulates programmed cell death induced by ultraviolet light and H2O2 in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_101508.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hydrogen peroxide-mediated programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-C IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    metacaspase 8
    NP_173092.1
    • metacaspase 8 (MC8); CONTAINS InterPro DOMAIN/s: Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 7 (TAIR:AT1G79310.1); Has 1067 Blast hits to 1064 proteins in 261 species: Archae - 3; Bacteria - 286; Metazoa - 0; Fungi - 258; Plants - 304; Viruses - 0; Other Eukaryotes - 216 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5612150..5614020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101508.4 → NP_173092.1  metacaspase 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q683B3, Q9SA41
      UniProtKB/TrEMBL
      A0A178WDC5
      Conserved Domains (1) summary
      pfam00656
      Location:3 → 167
      Peptidase_C14; Caspase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SA41.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools