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    ARP apurinic endonuclease-redox protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818744, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARP
    Official Full Name
    apurinic endonuclease-redox protein
    Primary source
    TAIR:AT2G41460
    Locus tag
    AT2G41460
    See related
    Araport:AT2G41460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    apurinic endonuclease-redox protein; T26J13.5; T26J13_5
    Summary
    apurinic endonuclease-redox protein. It functions as an apurinic/apyrimidinic class II endonuclease, and is involved in DNA repair.
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    Genomic context

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    See ARP in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (17285470..17289023)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase Neighboring gene glycosyltransferase-like protein Neighboring gene ncRNA Neighboring gene agamous-like MADS-box protein Neighboring gene F-box family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the catalytic mechanism of the AP endonuclease AtARP. Guo W, et al. Structure, 2024 Jun 6. PMID 38503293
    2. The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP is involved in the plant nucleotide incision repair pathway. Akishev Z, et al. DNA Repair (Amst), 2016 Dec. PMID 27836324
    3. The Arabidopsis thaliana apurinic endonuclease Arp reduces human transcription factors Fos and Jun. Babiychuk E, et al. Proc Natl Acad Sci U S A, 1994 Apr 12. PMID 7512729, Free PMC Article
    4. Arabidopsis ARP endonuclease functions in a branched base excision DNA repair pathway completed by LIG1. Córdoba-Cañero D, et al. Plant J, 2011 Nov. PMID 21781197
    5. The Arabidopsis DNA glycosylase MBD4L repairs the nuclear genome in vivo. Torres JR, et al. Plant J, 2023 Sep. PMID 37278489

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural insights into the catalytic mechanism of the AP endonuclease AtARP.
      Title: Structural insights into the catalytic mechanism of the AP endonuclease AtARP.
    2. The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP, is involved in the plant nucleotide incision repair pathway.
      Title: The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP is involved in the plant nucleotide incision repair pathway.
    3. ARP is the major AP endonuclease activity in Arabidopsis cells, and is required for base excision repair of both uracil and synthetic AP sites in vitro.
      Title: Arabidopsis ARP endonuclease functions in a branched base excision DNA repair pathway completed by LIG1.
    4. plants with knock-out mutations in any one of Ape1L, Ape2, or Arp show no apparent differences from wild type in growth rate, growth habit, and fertility
      Title: Requirement for abasic endonuclease gene homologues in Arabidopsis seed development.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001125028.1
    NM_001336913.1
    NM_001336914.1
    NM_129709.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphodiesterase I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    apurinic endonuclease-redox protein
    NP_001118500.1
    • apurinic endonuclease-redox protein (ARP); CONTAINS InterPro DOMAIN/s: DNA-binding SAP (InterPro:IPR003034), AP endonuclease, family 1, binding site (InterPro:IPR020847), Exodeoxyribonuclease III xth (InterPro:IPR004808), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: C2 calcium/lipid-binding endonuclease/exonuclease/phosphatase (TAIR:AT3G60950.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_181677.1
    • apurinic endonuclease-redox protein (ARP); CONTAINS InterPro DOMAIN/s: AP endonuclease, family 1, conserved site (InterPro:IPR020848), DNA-binding SAP (InterPro:IPR003034), AP endonuclease, family 1 (InterPro:IPR000097), AP endonuclease, family 1, binding site (InterPro:IPR020847), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135), Exodeoxyribonuclease III xth (InterPro:IPR004808); BEST Arabidopsis thaliana protein match is: C2 calcium/lipid-binding endonuclease/exonuclease/phosphatase (TAIR:AT3G60950.1); Has 8976 Blast hits to 8966 proteins in 2340 species: Archae - 119; Bacteria - 5352; Metazoa - 387; Fungi - 388; Plants - 165; Viruses - 2; Other Eukaryotes - 2563 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17285470..17289023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129709.5 → NP_181677.1  apurinic endonuclease-redox protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45951
      UniProtKB/TrEMBL
      A0A178VMT4, B2CJ89
      Conserved Domains (2) summary
      smart00513
      Location:97 → 131
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd09087
      Location:277 → 534
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family apurinic/apyrimidinic (AP) endonucleases

    2. NM_001336913.1 → NP_001323447.1  apurinic endonuclease-redox protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AX84, B2CJ89
      Conserved Domains (2) summary
      smart00513
      Location:90 → 124
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      cd09087
      Location:270 → 527
      Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family apurinic/apyrimidinic (AP) endonucleases

    3. NM_001125028.1 → NP_001118500.1  apurinic endonuclease-redox protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118500.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H7C2
      Conserved Domains (3) summary
      smart00513
      Location:97 → 131
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam06459
      Location:80 → 234
      RR_TM4-6; Ryanodine Receptor TM 4-6
      cl00490
      Location:277 → 400
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. NM_001336914.1 → NP_001323448.1  apurinic endonuclease-redox protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AX21, B2CJ89
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45951.2

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