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    ML5 MEI2-like protein 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839816, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ML5
    Official Full Name
    MEI2-like protein 5
    Primary source
    TAIR:AT1G29400
    Locus tag
    AT1G29400
    See related
    Araport:AT1G29400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AML5; F15D2.30; F15D2_30; MEI2-like protein 5
    Summary
    A member of mei2-like gene family, predominantly plant-based family of genes encoding RNA binding proteins with characteristic presence of a highly conserved RNA binding motif first described in the mei2 gene of the fission yeast S. pombe. In silico analyses reveal nine mei2 -like genes in A. thaliana. They were grouped into four distinct clades, based on overall sequence similarity and subfamily-specific sequence elements. AML5 is a member of two sister clades of mei2-like gene family, AML1 through AML5, and belongs to the clade named ALM235. Among mei2-like genes, AML5 is the transcript with highest frequency of alternative splicing. Expression was detected during embryo development (heart and torpedo stage) and in vegetative and floral apices.
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    Genomic context

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    See ML5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (10289998..10294630, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Carbohydrate-binding X8 domain superfamily protein Neighboring gene cold regulated 314 thylakoid membrane 2 Neighboring gene COLD REGULATED 314 INNER MEMBRANE 1 Neighboring gene phosphoribosylanthranilate isomerase 3 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis. Kaur J, et al. Plant Cell, 2006 Mar. PMID 16473967, Free PMC Article
    2. Substrates related to chromatin and to RNA-dependent processes are modified by Arabidopsis SUMO isoforms that differ in a conserved residue with influence on desumoylation. Budhiraja R, et al. Plant Physiol, 2009 Mar. PMID 19151129, Free PMC Article
    3. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711
    4. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
    5. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001332851.1
    NM_102680.2
    NM_179396.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    MEI2-like protein 5
    NP_174233.2
    • MEI2-like protein 5 (ML5); FUNCTIONS IN: RNA binding, nucleotide binding, nucleic acid binding; LOCATED IN: cellular_component unknown; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), RNA recognition motif 2 (InterPro:IPR007201), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: MEI2-like 3 (TAIR:AT4G18120.2); Has 6286 Blast hits to 5534 proteins in 358 species: Archae - 4; Bacteria - 106; Metazoa - 3187; Fungi - 1009; Plants - 1245; Viruses - 0; Other Eukaryotes - 735 (source: NCBI BLink).
    NP_849727.1
    • MEI2-like protein 5 (ML5); FUNCTIONS IN: RNA binding, nucleotide binding, nucleic acid binding; LOCATED IN: cellular_component unknown; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), RNA recognition motif 2 (InterPro:IPR007201), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: MEI2-like 3 (TAIR:AT4G18120.2); Has 6281 Blast hits to 5530 proteins in 358 species: Archae - 4; Bacteria - 106; Metazoa - 3185; Fungi - 1006; Plants - 1245; Viruses - 0; Other Eukaryotes - 735 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      10289998..10294630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179396.3 → NP_849727.1  MEI2-like protein 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLA0, Q8VWF5, Q9C7R1
      UniProtKB/TrEMBL
      A0A178W1W1, A0A5S9WAC0, A0A7G2DWM2
      Conserved Domains (3) summary
      cd12531
      Location:655 → 740
      RRM3_MEI2_like; RNA recognition motif 3 (RRM3) found in plant Mei2-like proteins
      cd12524
      Location:167 → 243
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins
      cd12529
      Location:252 → 322
      RRM2_MEI2_like; RNA recognition motif 2 (RRM2) found in plant Mei2-like proteins

    2. NM_001332851.1 → NP_001320501.1  MEI2-like protein 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLA0, Q8VWF5, Q9C7R1
      UniProtKB/TrEMBL
      A0A178W1W1, A0A5S9WAC0, A0A7G2DWM2
      Conserved Domains (3) summary
      cd12531
      Location:655 → 740
      RRM3_MEI2_like; RNA recognition motif 3 (RRM3) found in plant Mei2-like proteins
      cd12524
      Location:167 → 243
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins
      cd12529
      Location:252 → 322
      RRM2_MEI2_like; RNA recognition motif 2 (RRM2) found in plant Mei2-like proteins

    3. NM_102680.2 → NP_174233.2  MEI2-like protein 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174233.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLA0, Q8VWF5, Q9C7R1
      UniProtKB/TrEMBL
      A0A178W1W1, A0A5S9WAC0, A0A7G2DWM2
      Conserved Domains (3) summary
      cd12531
      Location:655 → 740
      RRM3_MEI2_like; RNA recognition motif 3 (RRM3) found in plant Mei2-like proteins
      cd12524
      Location:167 → 243
      RRM1_MEI2_like; RNA recognition motif 1 (RRM1) found in plant Mei2-like proteins
      cd12529
      Location:252 → 322
      RRM2_MEI2_like; RNA recognition motif 2 (RRM2) found in plant Mei2-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VWF5.1

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