Dclk1 doublecortin-like kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dclk1provided by MGI
Official Full Name: doublecortin-like kinase 1provided by MGI
Primary source: MGI:MGI:1330861
See related: Ensembl:ENSMUSG00000027797 AllianceGenome:MGI:1330861
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dcl; Dclk; Cpg16; Click-I; Dcamkl1; mKIAA0369; 1700113D08Rik; 2810480F11Rik
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]
Expression: Biased expression in frontal lobe adult (RPKM 35.3), cortex adult (RPKM 34.0) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 C; 3 26.53 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (55149724..55446489)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (55242303..55539068)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue.
Title: Doublecortin-like knockdown in mice attenuates obesity by stimulating energy expenditure in adipose tissue.
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome.
Title: Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome.
Blockage of DCLK1 in cardiomyocytes suppresses myocardial inflammation and alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic mice.
Title: Blockage of DCLK1 in cardiomyocytes suppresses myocardial inflammation and alleviates diabetic cardiomyopathy in streptozotocin-induced diabetic mice.
Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway.
Title: Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2/TAK1 signaling pathway.
Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses.
Title: Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses.
Doublecortin-like kinase 1 activates NF-kappaB to induce inflammatory responses by binding directly to IKKbeta.
Title: Doublecortin-like kinase 1 activates NF-κB to induce inflammatory responses by binding directly to IKKβ.
Doublecortin-Like Kinase 1 Facilitates Dendritic Spine Growth of Pyramidal Neurons in Mouse Prefrontal Cortex.
Title: Doublecortin-Like Kinase 1 Facilitates Dendritic Spine Growth of Pyramidal Neurons in Mouse Prefrontal Cortex.
DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis.
Title: DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis.
DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression via the MAPK/ERK/MMP2 Pathway.
Title: DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression via the MAPK/ERK/MMP2 Pathway.
Doublecortin-like expressing astrocytes of the suprachiasmatic nucleus are implicated in the biosynthesis of vasopressin and influences circadian rhythms.
Title: Doublecortin-like expressing astrocytes of the suprachiasmatic nucleus are implicated in the biosynthesis of vasopressin and influences circadian rhythms.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Mit208 (e-PCR), detects polymorphism
- UniSTS:129629

AI836758 (e-PCR)
- UniSTS:164207

RH139488 (e-PCR)
- UniSTS:221574

RH141097 (e-PCR)
- UniSTS:221574

RH140320 (e-PCR)
- UniSTS:222397

NoName (e-PCR)
- UniSTS:234685

Dclk1 (e-PCR), detects polymorphism
- UniSTS:515312

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon extension	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon extension	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to virus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase DCLK1

Names: CLICK-I beta; doublecortin and calcium/calmodulin-dependent protein kinase-like 1; doublecortin-like and CAM kinase-like 1

NP_001104521.1

EC 2.7.11.1

NP_001104522.1

EC 2.7.11.1

NP_001104523.1

EC 2.7.11.1

NP_001182467.1

EC 2.7.11.1

NP_001182468.1

EC 2.7.11.1

NP_001182469.1

EC 2.7.11.1

NP_001344395.1

EC 2.7.11.1

NP_001344397.1

EC 2.7.11.1

NP_001344398.1

EC 2.7.11.1

NP_001344404.1

EC 2.7.11.1

NP_001344405.1

EC 2.7.11.1

NP_064362.1

EC 2.7.11.1

XP_006501044.1

EC 2.7.11.1

XP_006501045.1

EC 2.7.11.1

XP_006501046.1

EC 2.7.11.1

XP_017174936.1

EC 2.7.11.1

XP_030108271.1

EC 2.7.11.1

XP_030108272.1

EC 2.7.11.1

XP_036018774.1

EC 2.7.11.1

XP_036018775.1

EC 2.7.11.1

XP_036018776.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111051.2 → NP_001104521.1 serine/threonine-protein kinase DCLK1 isoform 2

See identical proteins and their annotated locations for NP_001104521.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as DCLK-short-A, DCK-beta2, KIAA0369-BL or cpg16 (candidate plasticity gene 16)] is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, as compared to variant 5. The resulting isoform (2) has a shorter and different N-terminus, and lacks doublecortin domains, as compared to isoform 5.

Source sequence(s)

AC115945, AF155821, BF467198, BY123015

UniProtKB/TrEMBL

A0A0G2JE54, Q9JLM6

Related

ENSMUSP00000142637.2, ENSMUST00000198412.5

Conserved Domains (2) summary

smart00220
Location:83 → 340

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14183
Location:76 → 343

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_001111052.2 → NP_001104522.1 serine/threonine-protein kinase DCLK1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as DCLK-short-B, DCK-beta1 or KIAA0369-BS ) is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, and has an additional exon in the 3' CDS that results in a frameshift, as compared to variant 5. The resulting isoform (3) has shorter and different N- and C-termini, and lacks doublecortin domains, as compared to isoform 5.

Source sequence(s)

AC115945, BF467198

Consensus CDS

CCDS50910.1

UniProtKB/TrEMBL

A0A0G2JGH1, H7BX36

Related

ENSMUSP00000070292.5, ENSMUST00000070418.9

Conserved Domains (2) summary

smart00220
Location:83 → 340

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14183
Location:76 → 343

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_001111053.2 → NP_001104523.1 serine/threonine-protein kinase DCLK1 isoform 4

See identical proteins and their annotated locations for NP_001104523.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as DCL (PMID: 17313568)) is produced from the 5' promoter. It lacks several 3' exons but has an alternate 3' exon, as compared to variant 5. The resulting isoform (4) has a shorter and distinct C-terminus, and lacks a serine/proline-rich domain and a protein kinase domain, as compared to isoform 5.

Source sequence(s)

AC111132, AC115945, AK147831, BC050903, CJ241697

Consensus CDS

CCDS50909.1

UniProtKB/TrEMBL

Q3UGP0, Q80VB6, Q8VDT3

Related

ENSMUSP00000129334.2, ENSMUST00000167204.8

Conserved Domains (2) summary

cd17069
Location:182 → 265

DCX2; Dublecortin-like domain 2

cd17140
Location:55 → 143

DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
NM_001195538.2 → NP_001182467.1 serine/threonine-protein kinase DCLK1 isoform 5

See identical proteins and their annotated locations for NP_001182467.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as DCLK-long-A, DCK-alpha2, KIAA0369-AL, DCAMKL1 or zyg8) is produced from the 5' promoter. It encodes isoform 5, which includes two doublecortin domains, a serine/proline-rich domain and a protein kinase domain.

Source sequence(s)

AC104099, AC111132, AC115945, BF467198

UniProtKB/TrEMBL

A3KN70, Q8CHG1

Conserved Domains (3) summary

smart00220
Location:390 → 647

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:52 → 142

DCX; Domain in the Doublecortin (DCX) gene product

cd14183
Location:383 → 650

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_001195539.2 → NP_001182468.1 serine/threonine-protein kinase DCLK1 isoform 6

See identical proteins and their annotated locations for NP_001182468.1

Status: REVIEWED

Description

Transcript Variant: This variant (6, also known as DCLK-short-C or DCK-beta2-R) is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, and has an additional in-frame segment in the CDS, as compared to variant 5. The resulting isoform (6) has a shorter and different N-terminus, and lacks doublecortin domains but has an additional Arg-rich segment, as compared to isoform 5.

Source sequence(s)

AC115945, AF155821, AK032424, BF467198, BY123015

Consensus CDS

CCDS79909.1

UniProtKB/TrEMBL

A0A0G2JE54, Q8CCN4

Related

ENSMUSP00000143016.2, ENSMUST00000198437.5

Conserved Domains (2) summary

smart00220
Location:99 → 356

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14183
Location:92 → 359

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_001195540.2 → NP_001182469.1 serine/threonine-protein kinase DCLK1 isoform 7

See identical proteins and their annotated locations for NP_001182469.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) is produced from the 3' promoter. It shares only one exon with variant 5, and encodes a 56 aa isoform [7, also known as ania-4, or CARP (CaMK-related peptide)], which mainly consists of the serine/proline-rich domain.

Source sequence(s)

AC115945, BY126617

Consensus CDS

CCDS79908.1

UniProtKB/TrEMBL

A8IP62

Related

ENSMUSP00000142698.2, ENSMUST00000199585.5
NM_001357466.1 → NP_001344395.1 serine/threonine-protein kinase DCLK1 isoform 8

Status: REVIEWED

Source sequence(s)

AC104099, AC111132, AC115945, BF467198

UniProtKB/TrEMBL

Q8CHG1

Conserved Domains (2) summary

smart00537
Location:52 → 142

DCX; Domain in the Doublecortin (DCX) gene product

cd14183
Location:383 → 650

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_001357468.1 → NP_001344397.1 serine/threonine-protein kinase DCLK1 isoform 9

Status: REVIEWED

Source sequence(s)

AC115945, BF467198

UniProtKB/TrEMBL

A0A0G2JGH1

Conserved Domains (1) summary

cd14183
Location:92 → 359

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_001357469.1 → NP_001344398.1 serine/threonine-protein kinase DCLK1 isoform 10

Status: REVIEWED

Source sequence(s)

AC104099, AC111132, AC115945, BF467198

UniProtKB/TrEMBL

Q8CHG1

Conserved Domains (2) summary

smart00537
Location:52 → 142

DCX; Domain in the Doublecortin (DCX) gene product

cd14183
Location:399 → 666

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_001357475.1 → NP_001344404.1 serine/threonine-protein kinase DCLK1 isoform 11

Status: REVIEWED

Source sequence(s)

AC104099, AC111132, AC115945, BF467198

Consensus CDS

CCDS89626.1

UniProtKB/TrEMBL

A0A0G2JGQ6, Q8CHG1

Related

ENSMUSP00000143659.2, ENSMUST00000196745.5

Conserved Domains (2) summary

smart00537
Location:52 → 142

DCX; Domain in the Doublecortin (DCX) gene product

cd14183
Location:383 → 649

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_001357476.1 → NP_001344405.1 serine/threonine-protein kinase DCLK1 isoform 12

Status: REVIEWED

Source sequence(s)

AC115945, BF467198

Consensus CDS

CCDS89627.1

UniProtKB/TrEMBL

A0A0G2JGH1, Q1EDH1

Related

ENSMUSP00000143507.2, ENSMUST00000199702.5

Conserved Domains (1) summary

cd14183
Location:75 → 342

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
NM_019978.4 → NP_064362.1 serine/threonine-protein kinase DCLK1 isoform 1

See identical proteins and their annotated locations for NP_064362.1

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as DCLK-long-C, DCK-alpha2-R) is produced from the 5' promoter. It has an additional in-frame segment in the CDS, as compared to variant 5. The resulting isoform (1) is the longest isoform which includes an Arg-rich domain, in addition to two doublecortin domains, a serine/proline-rich domain and a protein kinase domain, as compared to isoform 5.

Source sequence(s)

AC111132, AC115945, AF155819, BF467198

Consensus CDS

CCDS17359.1

UniProtKB/Swiss-Prot

Q6P207, Q9JLM8

UniProtKB/TrEMBL

Q8CHG1

Related

ENSMUSP00000050034.8, ENSMUST00000054237.14

Conserved Domains (3) summary

smart00220
Location:406 → 663

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00537
Location:52 → 142

DCX; Domain in the Doublecortin (DCX) gene product

cd14183
Location:399 → 666

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

55149724..55446489

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319447.3 → XP_017174936.1 serine/threonine-protein kinase DCLK1 isoform X1

UniProtKB/TrEMBL

Q8CHG1

Conserved Domains (3) summary

cd14183
Location:399 → 666

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

cd17069
Location:182 → 265

DCX2; Dublecortin-like domain 2

cd17140
Location:55 → 143

DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
XM_036162883.1 → XP_036018776.1 serine/threonine-protein kinase DCLK1 isoform X8

UniProtKB/TrEMBL

Q3UGP0, Q80VB6, Q8VDT3

Conserved Domains (2) summary

cd17069
Location:182 → 265

DCX2; Dublecortin-like domain 2

cd17140
Location:55 → 143

DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
XM_006500983.5 → XP_006501046.1 serine/threonine-protein kinase DCLK1 isoform X8

See identical proteins and their annotated locations for XP_006501046.1

UniProtKB/TrEMBL

Q3UGP0, Q80VB6, Q8VDT3

Conserved Domains (2) summary

cd17069
Location:182 → 265

DCX2; Dublecortin-like domain 2

cd17140
Location:55 → 143

DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
XM_006500982.3 → XP_006501045.1 serine/threonine-protein kinase DCLK1 isoform X7

See identical proteins and their annotated locations for XP_006501045.1

UniProtKB/TrEMBL

Q3UGP0, Q8BRN4, Q8VDT3

Conserved Domains (2) summary

cd17069
Location:182 → 265

DCX2; Dublecortin-like domain 2

cd17140
Location:55 → 143

DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
XM_030252412.2 → XP_030108272.1 serine/threonine-protein kinase DCLK1 isoform X6

UniProtKB/TrEMBL

A0A0G2JGH1

Conserved Domains (1) summary

cd14183
Location:42 → 309

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
XM_006500981.5 → XP_006501044.1 serine/threonine-protein kinase DCLK1 isoform X2

See identical proteins and their annotated locations for XP_006501044.1

UniProtKB/TrEMBL

A0A0G2JE54

Conserved Domains (1) summary

cd14183
Location:58 → 325

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
XM_030252411.2 → XP_030108271.1 serine/threonine-protein kinase DCLK1 isoform X4

UniProtKB/TrEMBL

A0A0G2JE54

Conserved Domains (1) summary

cd14183
Location:42 → 309

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
XM_036162882.1 → XP_036018775.1 serine/threonine-protein kinase DCLK1 isoform X5

UniProtKB/TrEMBL

A0A0G2JE54

Conserved Domains (1) summary

cd14183
Location:41 → 308

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
XM_036162881.1 → XP_036018774.1 serine/threonine-protein kinase DCLK1 isoform X3

UniProtKB/TrEMBL

A0A0G2JE54

Conserved Domains (1) summary

cd14183
Location:57 → 324

STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)