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    SERPIN1 Serine protease inhibitor (SERPIN) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841182, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SERPIN1
    Official Full Name
    Serine protease inhibitor (SERPIN) family protein
    Primary source
    TAIR:AT1G47710
    Locus tag
    AT1G47710
    See related
    Araport:AT1G47710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSERPIN1; T2E6.22
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    Genomic context

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    See SERPIN1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (17557091..17560331)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene Primosome PriB/single-strand DNA-binding protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Singlet Oxygen-Induced Membrane Disruption and Serpin-Protease Balance in Vacuolar-Driven Cell Death. Koh E, et al. Plant Physiol, 2016 Jul. PMID 26884487, Free PMC Article
    2. AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta. Lema Asqui S, et al. New Phytol, 2018 May. PMID 28157265
    3. Set-point control of RD21 protease activity by AtSerpin1 controls cell death in Arabidopsis. Lampl N, et al. Plant J, 2013 May. PMID 23398119
    4. Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21). Lampl N, et al. J Biol Chem, 2010 Apr 30. PMID 20181955, Free PMC Article
    5. Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9. Vercammen D, et al. J Mol Biol, 2006 Dec 8. PMID 17028019

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtSerpin1 blocked AtMC1 self-processing and inhibited AtMC1-mediated cell death.
      Title: AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta.
    2. Serpin1 and WSCP differentially regulate the activity of RD21 during plant development in Arabidopsis thaliana.
      Title: Serpin1 and WSCP differentially regulate the activity of the cysteine protease RD21 during plant development in Arabidopsis thaliana.
    3. The GLV1 precursor is a direct subtilase substrate. The elimination of the in vitro subtilase recognition sites through alanine substitution suppressed the GLV1 gain-of-function phenotype in vivo. The protease inhibitor Serpin1 bound to SBT6.1 and inhibited the cleavage of GLV1 precursors by the protease.
      Title: The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation.
    4. Serpin1 in the cytoplasm can partially protect cells from vacuolar-mediated cell death.
      Title: Singlet Oxygen-Induced Membrane Disruption and Serpin-Protease Balance in Vacuolar-Driven Cell Death.
    5. AtSerpin1 and RD21 can modulate necrotroph-induced cell death.
      Title: Set-point control of RD21 protease activity by AtSerpin1 controls cell death in Arabidopsis.
    6. AtSerpin1, which was found to be a potent inhibitor of AtMC9 activity in vitro through cleavage of its reactive center loop and covalent binding to AtMC9. [AtSerpin1]
      Title: Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_103664.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Serine protease inhibitor (SERPIN) family protein
    NP_175202.1
    • Serine protease inhibitor (SERPIN) family protein; FUNCTIONS IN: serine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity; INVOLVED IN: biological_process unknown; LOCATED IN: apoplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protease inhibitor I4, serpin, plant (InterPro:IPR015554), Protease inhibitor I4, serpin (InterPro:IPR000215); BEST Arabidopsis thaliana protein match is: Serine protease inhibitor (SERPIN) family protein (TAIR:AT3G45220.1); Has 6643 Blast hits to 6565 proteins in 500 species: Archae - 66; Bacteria - 387; Metazoa - 5142; Fungi - 12; Plants - 353; Viruses - 463; Other Eukaryotes - 220 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17557091..17560331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333282.1 → NP_001320925.1  Serine protease inhibitor (SERPIN) family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8API2, A0A654EH51

    2. NM_103664.4 → NP_175202.1  Serine protease inhibitor (SERPIN) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9S7T8
      UniProtKB/TrEMBL
      A0A178W8B7, A0A5S9WMY8, A0A654EH51
      Conserved Domains (1) summary
      cd02043
      Location:8 → 389
      serpinP_plants; serpin family P, plant serpins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S7T8.1

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