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    KDM6A lysine demethylase 6A [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 100427119, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KDM6Aprovided by VGNC
    Official Full Name
    lysine demethylase 6Aprovided by VGNC
    Primary source
    VGNC:VGNC:73820
    See related
    Ensembl:ENSMMUG00000003317
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See KDM6A in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) X NC_041774.1 (44781309..45018013)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) X NC_027913.1 (44961912..45197805)

    Chromosome X - NC_041774.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC114674935 Neighboring gene chromosome transmission fidelity protein 8 homolog pseudogene Neighboring gene dual specificity phosphatase 21 Neighboring gene divergent protein kinase domain 2B Neighboring gene plasmolipin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K27me2/H3K27me3 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysine-specific demethylase 6A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041774.1 Reference Mmul_10 Primary Assembly

      Range
      44781309..45018013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015127247.2 → XP_014982733.1  lysine-specific demethylase 6A isoform X1

      UniProtKB/TrEMBL
      A0A5F8AHK0, F7EHL1
      Related
      ENSMMUP00000004426.4, ENSMMUT00000004693.4
      Conserved Domains (4) summary
      smart00558
      Location:1151 → 1215
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:1185 → 1293
      JmjC; JmjC domain, hydroxylase

    2. XM_015127249.2 → XP_014982735.1  lysine-specific demethylase 6A isoform X3

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (4) summary
      pfam02373
      Location:1185 → 1293
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1151 → 1215
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]

    3. XM_015127248.2 → XP_014982734.1  lysine-specific demethylase 6A isoform X2

      UniProtKB/TrEMBL
      A0A5F8AHK0
      Conserved Domains (4) summary
      smart00558
      Location:1117 → 1181
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:1151 → 1259
      JmjC; JmjC domain, hydroxylase

    4. XM_015127252.2 → XP_014982738.1  lysine-specific demethylase 6A isoform X6

      UniProtKB/TrEMBL
      A0A1D5Q6W5, H9FZD5, I2CV02
      Related
      ENSMMUP00000043781.2, ENSMMUT00000075094.2
      Conserved Domains (5) summary
      pfam02373
      Location:1151 → 1259
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1117 → 1181
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      cl25496
      Location:430 → 788
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    5. XM_015127251.2 → XP_014982737.1  lysine-specific demethylase 6A isoform X5

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (4) summary
      smart00558
      Location:1099 → 1163
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:1133 → 1241
      JmjC; JmjC domain, hydroxylase

    6. XM_015127256.2 → XP_014982742.1  lysine-specific demethylase 6A isoform X10

      UniProtKB/TrEMBL
      A0A5F8A1Y9, H9FZD5, I2CV02
      Related
      ENSMMUP00000070911.1, ENSMMUT00000092809.1
      Conserved Domains (4) summary
      pfam02373
      Location:1133 → 1241
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1099 → 1163
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]

    7. XM_015127255.2 → XP_014982741.1  lysine-specific demethylase 6A isoform X9

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (4) summary
      smart00558
      Location:1065 → 1129
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:1099 → 1207
      JmjC; JmjC domain, hydroxylase

    8. XM_015127259.2 → XP_014982745.1  lysine-specific demethylase 6A isoform X13

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (5) summary
      pfam02373
      Location:1099 → 1207
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1065 → 1129
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 399
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam15782
      Location:417 → 579
      GREB1; Gene regulated by oestrogen in breast cancer

    9. XM_015127250.2 → XP_014982736.1  lysine-specific demethylase 6A isoform X4

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (4) summary
      smart00558
      Location:1106 → 1170
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 401
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:1140 → 1248
      JmjC; JmjC domain, hydroxylase

    10. XM_015127254.2 → XP_014982740.1  lysine-specific demethylase 6A isoform X8

      UniProtKB/TrEMBL
      F7BRN8, H9FZD5, I2CV02
      Related
      ENSMMUP00000041109.3, ENSMMUT00000048072.3
      Conserved Domains (4) summary
      pfam02373
      Location:1140 → 1248
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1106 → 1170
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 401
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]

    11. XM_015127253.2 → XP_014982739.1  lysine-specific demethylase 6A isoform X7

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (4) summary
      smart00558
      Location:1072 → 1136
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 401
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:1106 → 1214
      JmjC; JmjC domain, hydroxylase

    12. XM_015127258.2 → XP_014982744.1  lysine-specific demethylase 6A isoform X12

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (6) summary
      pfam02373
      Location:1106 → 1214
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1072 → 1136
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:106 → 401
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:130 → 163
      TPR_1; Tetratricopeptide repeat
      pfam13431
      Location:272 → 303
      TPR_17; Tetratricopeptide repeat

    13. XM_015127257.2 → XP_014982743.1  lysine-specific demethylase 6A isoform X11

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (5) summary
      smart00558
      Location:1054 → 1118
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:47 → 315
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG4235
      Location:269 → 372
      NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:1088 → 1196
      JmjC; JmjC domain, hydroxylase

    14. XM_015127260.2 → XP_014982746.1  lysine-specific demethylase 6A isoform X14

      UniProtKB/TrEMBL
      A0A1D5QEA4, H9FZD5, I2CV02
      Related
      ENSMMUP00000046373.2, ENSMMUT00000055811.2
      Conserved Domains (5) summary
      pfam02373
      Location:1088 → 1196
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1054 → 1118
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:47 → 315
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      cl28296
      Location:269 → 372
      NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]

    15. XM_015127261.2 → XP_014982747.1  lysine-specific demethylase 6A isoform X15

      UniProtKB/TrEMBL
      H9FZD5, I2CV02
      Conserved Domains (5) summary
      pfam02373
      Location:1054 → 1162
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:1020 → 1084
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:47 → 315
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      cl28296
      Location:269 → 372
      NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]

    RNA

    1. XR_001441950.2 RNA Sequence

    2. XR_003725955.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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