PTPN3 protein tyrosine phosphatase non-receptor type 3 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PTPN3provided by VGNC
Official Full Name: protein tyrosine phosphatase non-receptor type 3provided by VGNC
Primary source: VGNC:VGNC:76604
Locus tag: EGK_07446
See related: Ensembl:ENSMMUG00000001250
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	15	NC_041768.1 (33401146..33523143)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	15	NC_027907.1 (30051712..30174035)

Chromosome 15 - NC_041768.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH78381 (e-PCR)
- UniSTS:38153

PTPN3_2445 (e-PCR)
- UniSTS:280941

STS-W15441 (e-PCR)
- UniSTS:82348

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 3

XP_014972609.1

EC 3.1.3.48

XP_014972610.1

EC 3.1.3.48

XP_014972611.1

EC 3.1.3.48

XP_014972612.1

EC 3.1.3.48

XP_014972613.1

EC 3.1.3.48

XP_014972614.1

EC 3.1.3.48

XP_014972615.1

EC 3.1.3.48

XP_014972616.1

EC 3.1.3.48

XP_028690826.1

EC 3.1.3.48

XP_028690827.1

EC 3.1.3.48

XP_028690828.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041768.1 Reference Mmul_10 Primary Assembly

Range

33401146..33523143

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015117123.2 → XP_014972609.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

UniProtKB/TrEMBL

A0A5F7ZVI7, A0A8J8YIZ4, F7HG49, G7NEJ9

Related

ENSMMUP00000075278.1, ENSMMUT00000084704.1

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_015117126.2 → XP_014972612.1 tyrosine-protein phosphatase non-receptor type 3 isoform X3

UniProtKB/TrEMBL

A0A5F7ZVI7, F7D361, I2CTP1

Related

ENSMMUP00000001672.3, ENSMMUT00000001775.4

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:463 → 550

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:586 → 859

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_015117125.2 → XP_014972611.1 tyrosine-protein phosphatase non-receptor type 3 isoform X2

UniProtKB/TrEMBL

A0A5F7ZVI7

Related

ENSMMUP00000067192.1, ENSMMUT00000082025.1

Conserved Domains (7) summary

smart00194
Location:634 → 885

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:31 → 207

B41; Band 4.1 homologues

cd00047
Location:657 → 884

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00992
Location:493 → 580

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:201 → 294

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam00373
Location:121 → 207

FERM_M; FERM central domain

pfam09379
Location:33 → 96

FERM_N; FERM N-terminal domain
XM_015117127.2 → XP_014972613.1 tyrosine-protein phosphatase non-receptor type 3 isoform X4

UniProtKB/TrEMBL

A0A5F7ZVI7

Conserved Domains (4) summary

cd00992
Location:399 → 486

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:107 → 200

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:522 → 795

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

pfam00373
Location:9 → 113

FERM_M; FERM central domain
XM_015117129.2 → XP_014972615.1 tyrosine-protein phosphatase non-receptor type 3 isoform X6

UniProtKB/TrEMBL

A0A5F7ZVI7

Conserved Domains (4) summary

smart00295
Location:2 → 91

B41; Band 4.1 homologues

cd00992
Location:377 → 464

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:85 → 178

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:500 → 773

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_015117128.2 → XP_014972614.1 tyrosine-protein phosphatase non-receptor type 3 isoform X5

UniProtKB/TrEMBL

A0A5F7ZVI7

Conserved Domains (4) summary

smart00295
Location:6 → 98

B41; Band 4.1 homologues

cd00992
Location:384 → 471

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:92 → 185

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:507 → 780

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_015117124.2 → XP_014972610.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

UniProtKB/TrEMBL

A0A5F7ZVI7, A0A8J8YIZ4, F7HG49, G7NEJ9

Related

ENSMMUP00000039654.2, ENSMMUT00000046618.3

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_028834994.1 → XP_028690827.1 tyrosine-protein phosphatase non-receptor type 3 isoform X7

UniProtKB/TrEMBL

A0A5F7ZVI7

Conserved Domains (4) summary

cd00992
Location:358 → 445

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:66 → 159

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam00373
Location:6 → 72

FERM_M; FERM central domain

cd14600
Location:481 → 754

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_028834995.1 → XP_028690828.1 tyrosine-protein phosphatase non-receptor type 3 isoform X8

Conserved Domains (3) summary

cd00992
Location:276 → 363

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14600
Location:399 → 672

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

cl17171
Location:1 → 77

PH-like; Pleckstrin homology-like domain
XM_028834993.1 → XP_028690826.1 tyrosine-protein phosphatase non-receptor type 3 isoform X7

UniProtKB/TrEMBL

A0A5F7ZVI7

Conserved Domains (4) summary

cd00992
Location:358 → 445

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:66 → 159

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam00373
Location:6 → 72

FERM_M; FERM central domain

cd14600
Location:481 → 754

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_015117130.1 → XP_014972616.1 tyrosine-protein phosphatase non-receptor type 3 isoform X8

Conserved Domains (3) summary

cd00992
Location:276 → 363

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14600
Location:399 → 672

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

cl17171
Location:1 → 77

PH-like; Pleckstrin homology-like domain