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    PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 710115, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PIKFYVEprovided by VGNC
    Official Full Name
    phosphoinositide kinase, FYVE-type zinc finger containingprovided by VGNC
    Primary source
    VGNC:VGNC:75854
    See related
    Ensembl:ENSMMUG00000017524
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Orthologs
    human mouse all
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    Genomic context

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    See PIKFYVE in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 12 NC_041765.1 (95679237..95771351)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 12 NC_027904.1 (90036336..90128262)

    Chromosome 12 - NC_041765.1Genomic Context describing neighboring genes Neighboring gene translationally-controlled tumor protein-like Neighboring gene uncharacterized LOC114671484 Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene parathyroid hormone 2 receptor Neighboring gene 40S ribosomal protein SA-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 3-phosphate 5-kinase
    XP_001108540.2
    XP_014966307.2
    XP_014966308.2
    XP_014966309.2
    XP_014966310.2
    XP_014966311.2
    XP_014966312.2
    XP_014966313.2
    XP_014966315.2
    XP_014966316.2
    XP_014966317.2
    XP_014966318.2
    XP_014966319.2
    XP_014966320.2
    XP_014966321.2
    XP_014966322.2
    XP_014966323.1
    XP_014966324.1
    XP_028686886.1
    XP_028686887.1
    XP_028686888.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041765.1 Reference Mmul_10 Primary Assembly

      Range
      95679237..95771351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015110837.2 → XP_014966323.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

      Conserved Domains (1) summary
      cd04448
      Location:260 → 341
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

    2. XM_015110821.2 → XP_014966307.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZWQ3, H9Z655
      Related
      ENSMMUP00000069603.1, ENSMMUT00000106985.1
      Conserved Domains (4) summary
      cd03334
      Location:629 → 889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369 → 450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166 → 227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1830 → 2096
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    3. XM_028831053.1 → XP_028686886.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

      UniProtKB/TrEMBL
      A0A5F7ZSL7, H9Z655
      Related
      ENSMMUP00000067633.1, ENSMMUT00000092513.1
      Conserved Domains (5) summary
      COG5253
      Location:1520 → 2087
      MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
      cd03334
      Location:629 → 889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369 → 450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166 → 227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1810 → 2076
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    4. XM_028831054.1 → XP_028686887.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

      UniProtKB/TrEMBL
      F7AV30, H9Z655
      Related
      ENSMMUP00000037766.3, ENSMMUT00000044747.3
      Conserved Domains (5) summary
      COG5253
      Location:1520 → 2079
      MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
      cd03334
      Location:629 → 889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369 → 450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166 → 227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1802 → 2068
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    5. XM_015110826.2 → XP_014966312.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

      UniProtKB/TrEMBL
      A0A5F7ZGR9, H9Z655
      Related
      ENSMMUP00000064828.1, ENSMMUT00000093155.1
      Conserved Domains (4) summary
      cd03334
      Location:573 → 833
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369 → 450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166 → 227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1774 → 2040
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    6. XM_015110824.2 → XP_014966310.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (4) summary
      cd03334
      Location:623 → 883
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369 → 450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166 → 227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1824 → 2090
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    7. XM_015110829.2 → XP_014966315.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X9

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (4) summary
      cd03334
      Location:567 → 827
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369 → 450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166 → 227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1768 → 2034
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    8. XM_015110830.2 → XP_014966316.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X10

      UniProtKB/TrEMBL
      A0A5F8AAP9, H9Z655
      Related
      ENSMMUP00000074456.1, ENSMMUT00000090014.1
      Conserved Domains (3) summary
      cd03334
      Location:532 → 792
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:272 → 353
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd17300
      Location:1733 → 1999
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    9. XM_015110823.2 → XP_014966309.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

      UniProtKB/TrEMBL
      H9Z655
      Related
      ENSMMUP00000061248.1, ENSMMUT00000108698.1
      Conserved Domains (4) summary
      cd03334
      Location:628 → 888
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:368 → 449
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:165 → 226
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1829 → 2095
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    10. XM_015110827.2 → XP_014966313.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (4) summary
      cd03334
      Location:572 → 832
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:368 → 449
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:165 → 226
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1773 → 2039
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    11. XM_015110831.2 → XP_014966317.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (3) summary
      cd03334
      Location:531 → 791
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:271 → 352
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd17300
      Location:1732 → 1998
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    12. XM_015110825.2 → XP_014966311.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZCX9, A0A8J8YAQ4, G7N8S8, H9Z655
      Related
      ENSMMUP00000063436.1, ENSMMUT00000081367.1
      Conserved Domains (4) summary
      cd03334
      Location:617 → 877
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:357 → 438
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:154 → 215
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1818 → 2084
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    13. XM_015110833.2 → XP_014966319.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X12

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (3) summary
      cd03334
      Location:520 → 780
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:260 → 341
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd17300
      Location:1721 → 1987
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    14. XM_015110835.2 → XP_014966321.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X13

      UniProtKB/TrEMBL
      A0A5F8AKB7, H9Z655
      Related
      ENSMMUP00000077851.1, ENSMMUT00000089913.1
      Conserved Domains (3) summary
      cd03334
      Location:470 → 730
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:210 → 291
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd17300
      Location:1671 → 1937
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    15. XM_001108540.4 → XP_001108540.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

      UniProtKB/TrEMBL
      A0A5F7ZCX9, A0A8J8YAQ4, G7N8S8, H9Z655
      Conserved Domains (4) summary
      cd03334
      Location:617 → 877
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:357 → 438
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:154 → 215
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1818 → 2084
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    16. XM_015110836.2 → XP_014966322.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X15

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (4) summary
      COG5253
      Location:1189 → 1776
      MSS4; Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]
      cd03334
      Location:298 → 558
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:38 → 119
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd17300
      Location:1499 → 1765
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    17. XM_015110822.2 → XP_014966308.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      UniProtKB/TrEMBL
      A0A5F7ZWQ3, H9Z655
      Conserved Domains (4) summary
      cd03334
      Location:629 → 889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369 → 450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166 → 227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:1830 → 2096
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    18. XM_015110832.2 → XP_014966318.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (3) summary
      cd03334
      Location:531 → 791
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:271 → 352
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd17300
      Location:1732 → 1998
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    19. XM_015110834.2 → XP_014966320.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform X12

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (3) summary
      cd03334
      Location:520 → 780
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:260 → 341
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd17300
      Location:1721 → 1987
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

    20. XM_015110838.1 → XP_014966324.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

      Conserved Domains (1) summary
      cd04448
      Location:260 → 341
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

    21. XM_028831055.1 → XP_028686888.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X14

      UniProtKB/TrEMBL
      H9Z655
      Conserved Domains (3) summary
      cd03334
      Location:417 → 677
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:157 → 238
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd17300
      Location:1618 → 1884
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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