NSD1 nuclear receptor binding SET domain protein 1 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: NSD1provided by VGNC
Official Full Name: nuclear receptor binding SET domain protein 1provided by VGNC
Primary source: VGNC:VGNC:75401
See related: Ensembl:ENSMMUG00000009041
Gene type: protein coding
RefSeq status: MODEL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	6	NC_041759.1 (174609232..174787102)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	6	NC_027898.1 (175762826..175941044)

Chromosome 6 - NC_041759.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

WI-14959 (e-PCR)
- UniSTS:32007

RH68619 (e-PCR)
- UniSTS:59179

D5S2221E (e-PCR)
- UniSTS:154427

RH68301 (e-PCR)
- UniSTS:26699

D5S2260E (e-PCR)
- UniSTS:154466

RH80203 (e-PCR)
- UniSTS:84323

NoName (e-PCR)
- UniSTS:486645

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables histone H3K36 methyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

XP_014996983.1

EC 2.1.1.354

XP_014996985.1

EC 2.1.1.354

XP_014996986.1

EC 2.1.1.354

XP_014996988.1

EC 2.1.1.354

XP_028705776.1

EC 2.1.1.354

XP_028705777.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041759.1 Reference Mmul_10 Primary Assembly

Range

174609232..174787102

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015141499.2 → XP_014996985.1 histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1

UniProtKB/TrEMBL

F7FC96, G7MU35

Related

ENSMMUP00000011851.4, ENSMMUT00000012638.4

Conserved Domains (10) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1753 → 1847

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1890 → 1940

AWS; associated with SET domains

smart00317
Location:1941 → 2064

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG5034
Location:1430 → 1586

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1544 → 1586

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1591 → 1637

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1638 → 1691

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1708 → 1747

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:2119 → 2161

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_015141502.2 → XP_014996988.1 histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X3

UniProtKB/TrEMBL

F7FC87, H9ZCC1

Conserved Domains (11) summary

cd05837
Location:50 → 160

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1484 → 1578

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1621 → 1671

AWS; associated with SET domains

smart00317
Location:1672 → 1795

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

PHA03247
Location:1938 → 2321

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1161 → 1317

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1275 → 1317

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1322 → 1368

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1369 → 1422

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1439 → 1478

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1850 → 1892

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_028849943.1 → XP_028705776.1 histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X3

UniProtKB/TrEMBL

F7FC87, H9ZCC1

Related

ENSMMUP00000079253.1, ENSMMUT00000083371.1

Conserved Domains (11) summary

cd05837
Location:50 → 160

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1484 → 1578

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1621 → 1671

AWS; associated with SET domains

smart00317
Location:1672 → 1795

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

PHA03247
Location:1938 → 2321

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1161 → 1317

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1275 → 1317

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1322 → 1368

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1369 → 1422

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1439 → 1478

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1850 → 1892

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_015141497.2 → XP_014996983.1 histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1

UniProtKB/TrEMBL

F7FC96, G7MU35

Conserved Domains (10) summary

cd05837
Location:319 → 429

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1753 → 1847

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1890 → 1940

AWS; associated with SET domains

smart00317
Location:1941 → 2064

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG5034
Location:1430 → 1586

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1544 → 1586

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1591 → 1637

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1638 → 1691

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1708 → 1747

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:2119 → 2161

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_015141500.2 → XP_014996986.1 histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X2

UniProtKB/TrEMBL

G7MU35

Conserved Domains (10) summary

cd05837
Location:179 → 289

MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...

cd05838
Location:1613 → 1707

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1750 → 1800

AWS; associated with SET domains

smart00317
Location:1801 → 1924

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG5034
Location:1290 → 1446

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1404 → 1446

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1451 → 1497

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1498 → 1551

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1568 → 1607

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1979 → 2021

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)
XM_028849944.1 → XP_028705777.1 histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X4

UniProtKB/TrEMBL

F7FC87

Conserved Domains (11) summary

cd05838
Location:1400 → 1494

WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...

smart00570
Location:1537 → 1587

AWS; associated with SET domains

smart00317
Location:1588 → 1711

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

PHA03247
Location:1854 → 2237

PHA03247; large tegument protein UL36; Provisional

COG5034
Location:1077 → 1233

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15648
Location:1191 → 1233

PHD1_NSD1_2; PHD finger 1 found in nuclear receptor-binding SET domain-containing protein NSD1 and NSD2

cd15650
Location:1238 → 1284

PHD2_NSD1; PHD finger 2 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15653
Location:1285 → 1338

PHD3_NSD1; PHD finger 3 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15656
Location:1355 → 1394

PHD4_NSD1; PHD finger 4 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cd15659
Location:1766 → 1808

PHD5_NSD1; PHD finger 5 found in nuclear receptor-binding SET domain-containing protein 1 (NSD1)

cl02554
Location:3 → 76

PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...