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    CISH cytokine inducible SH2 containing protein [ Equus asinus (ass) ]

    Gene ID: 106830740, updated on 13-Mar-2024

    Summary

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    Gene symbol
    CISH
    Gene description
    cytokine inducible SH2 containing protein
    See related
    Ensembl:ENSEASG00005025940
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus asinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See CISH in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    101 current ASM1607732v2 (GCF_016077325.2) 21 NC_052197.1 (60131322..60136871, complement)
    100 previous assembly ASM130575v1 (GCF_001305755.1) Unplaced Scaffold NW_014637477.1 (1774814..1780129, complement)

    Chromosome 21 - NC_052197.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC123279624 Neighboring gene chromosome 21 C3orf18 homolog Neighboring gene HemK methyltransferase family member 1 Neighboring gene MAPK activated protein kinase 3 Neighboring gene dedicator of cytokinesis 3 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytokine-inducible SH2-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Equus asinus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM1607732v2

    Genomic

    1. NC_052197.1 Reference ASM1607732v2

      Range
      60131322..60136871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014840538.2 → XP_014696024.1  cytokine-inducible SH2-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A8C4PN02, A0A9L0JVP1
      Conserved Domains (2) summary
      cd10718
      Location:77 → 164
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
      cd03734
      Location:217 → 257
      SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

    2. XM_014840537.2 → XP_014696023.1  cytokine-inducible SH2-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A9L0JVP1, A0A9L0K683
      Related
      ENSEASP00005057882.1, ENSEAST00005062994.1
      Conserved Domains (2) summary
      cd10718
      Location:111 → 198
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
      cd03734
      Location:251 → 291
      SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

    3. XM_014840539.2 → XP_014696025.1  cytokine-inducible SH2-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A9L0JVP1
      Conserved Domains (2) summary
      cd10718
      Location:115 → 202
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
      cd03734
      Location:255 → 295
      SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...
    Nucleotide Protein
    Heading Accession and Version

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