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    LOC101393593 cytokine inducible SH2 containing protein [ Ceratotherium simum simum (southern white rhinoceros) ]

    Gene ID: 101393593, updated on 8-Mar-2024

    Summary

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    Gene symbol
    LOC101393593
    Gene description
    cytokine inducible SH2 containing protein
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ceratotherium simum simum (sub-species: simum)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae; Ceratotherium
    Also known as
    CISH
    Orthologs
    human mouse all
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    Genomic context

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    See LOC101393593 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    101 current CerSimSim1.0 (GCF_000283155.1) Unplaced Scaffold NW_004454158.1 (48702106..48707429, complement)

    NW_004454158.1Genomic Context describing neighboring genes Neighboring gene chromosome unknown C3orf18 homolog Neighboring gene HemK methyltransferase family member 1 Neighboring gene MAPK activated protein kinase 3 Neighboring gene dedicator of cytokinesis 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004454158.1 Unplaced Scaffold Reference CerSimSim1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytokine-inducible SH2-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Ceratotherium simum simum Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CerSimSim1.0 Primary Assembly

    Genomic

    1. NW_004454158.1 Reference CerSimSim1.0 Primary Assembly

      Range
      48702106..48707429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004419755.2 → XP_004419812.1  cytokine-inducible SH2-containing protein isoform X2

      Conserved Domains (2) summary
      cd10718
      Location:77 → 164
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
      cd03734
      Location:217 → 257
      SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

    2. XM_014792533.1 → XP_014648019.1  cytokine-inducible SH2-containing protein isoform X1

      Conserved Domains (2) summary
      cd10718
      Location:111 → 198
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
      cd03734
      Location:251 → 291
      SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...

    3. XM_014792540.1 → XP_014648026.1  cytokine-inducible SH2-containing protein isoform X3

      Conserved Domains (2) summary
      cd10718
      Location:115 → 202
      SH2_CIS; Src homology 2 (SH2) domain found in cytokine-inducible SH2-containing protein (CIS)
      cd03734
      Location:255 → 295
      SOCS_CIS1; SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. ...
    Nucleotide Protein
    Heading Accession and Version

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