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    Prxl2a peroxiredoxin like 2A [ Mus musculus (house mouse) ]

    Gene ID: 70564, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prxl2aprovided by MGI
    Official Full Name
    peroxiredoxin like 2Aprovided by MGI
    Primary source
    MGI:MGI:1917814
    See related
    Ensembl:ENSMUSG00000021792 AllianceGenome:MGI:1917814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adrx; Pamm; Fam213a; 5730469M10Rik
    Summary
    Predicted to enable antioxidant activity. Predicted to be involved in regulation of osteoclast differentiation. Located in mitochondrion. Is expressed in several structures, including alimentary system; ganglia; lung; sensory organ; and urinary system. Orthologous to human PRXL2A (peroxiredoxin like 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E18 (RPKM 29.4), cerebellum adult (RPKM 24.5) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prxl2a in Genome Data Viewer
    Location:
    14 B; 14 22.36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (40715692..40735790, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (40993735..41013833, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 14 Neighboring gene STARR-positive B cell enhancer ABC_E9893 Neighboring gene VISTA enhancer mm1503 Neighboring gene STARR-positive B cell enhancer ABC_E4105 Neighboring gene STARR-positive B cell enhancer ABC_E8554 Neighboring gene predicted gene, 31839 Neighboring gene STARR-positive B cell enhancer ABC_E5429 Neighboring gene STARR-seq mESC enhancer starr_36477 Neighboring gene DPY30 domain containing 2 Neighboring gene DPY30 domain containing 1 Neighboring gene methionine adenosyltransferase 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antioxidant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables antioxidant activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables antioxidant activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    peroxiredoxin-like 2A
    Names
    Adiporedoxin
    UPF0765 protein C10orf58 homolog
    family with sequence similarity 213, member A
    peroxiredoxin-like 2 activated in M-CSF stimulated monocytes
    redox-regulatory protein FAM213A
    redox-regulatory protein PAMM

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316732.1NP_001303661.1  peroxiredoxin-like 2A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC154597, AI840708, AK017688, CN690987, CX238562
      UniProtKB/TrEMBL
      D3Z252
      Conserved Domains (1) summary
      cd02970
      Location:51204
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    2. NM_001316733.1NP_001303662.1  peroxiredoxin-like 2A isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC154597, AI840708, AK017688, BY230987, CX238562
      UniProtKB/TrEMBL
      D3Z252
      Conserved Domains (1) summary
      cd02970
      Location:51204
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    3. NM_001316734.1NP_001303663.1  peroxiredoxin-like 2A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AC154597, AI840708, AK017688, BY075270, CX238562
      Consensus CDS
      CCDS84116.1
      UniProtKB/TrEMBL
      D3Z252, Q3U125
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    4. NM_001316735.1NP_001303664.1  peroxiredoxin-like 2A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AC154597, AI840708, AK017688, CX238562
      Consensus CDS
      CCDS84116.1
      UniProtKB/TrEMBL
      D3Z252, Q3U125
      Related
      ENSMUSP00000112377.2, ENSMUST00000118466.8
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    5. NM_001316736.1NP_001303665.1  peroxiredoxin-like 2A isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 3, 4, and 5 all encode the same isoform (b).
      Source sequence(s)
      AC154597, AI840708, AK017688, BY226409, CX238562, W97644
      Consensus CDS
      CCDS84116.1
      UniProtKB/TrEMBL
      D3Z252, Q3U125
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    6. NM_001316737.1NP_001303666.1  peroxiredoxin-like 2A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 6, 7, and 8 all encode the same isoform (c).
      Source sequence(s)
      AC154597, AI840708, AK017688, BY286698, CX238562
      Consensus CDS
      CCDS26957.1
      UniProtKB/Swiss-Prot
      Q9CYH2
      UniProtKB/TrEMBL
      D3Z252
      Conserved Domains (1) summary
      cd02970
      Location:37190
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    7. NM_001316739.1NP_001303668.1  peroxiredoxin-like 2A isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 6, 7, and 8 all encode the same isoform (c).
      Source sequence(s)
      AC154597, AI840708, AK017688, CX238562, W97644
      Consensus CDS
      CCDS26957.1
      UniProtKB/Swiss-Prot
      Q9CYH2
      UniProtKB/TrEMBL
      D3Z252
      Related
      ENSMUSP00000122866.2, ENSMUST00000130166.8
      Conserved Domains (1) summary
      cd02970
      Location:37190
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    8. NM_001316740.1NP_001303669.1  peroxiredoxin-like 2A isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC154597, AI840708, AK017688, BY140069, CX238562
      UniProtKB/TrEMBL
      D3Z252
      Conserved Domains (1) summary
      cd02970
      Location:44197
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    9. NM_001378813.1NP_001365742.1  peroxiredoxin-like 2A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154597
      UniProtKB/TrEMBL
      D3Z252, Q3U125
      Related
      ENSMUSP00000121795.2, ENSMUST00000136661.8
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    10. NM_001378814.1NP_001365743.1  peroxiredoxin-like 2A isoform b

      Status: VALIDATED

      Source sequence(s)
      AC154597
      UniProtKB/TrEMBL
      D3Z252, Q3U125
      Conserved Domains (1) summary
      cd02970
      Location:48201
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    11. NM_001378815.1NP_001365744.1  peroxiredoxin-like 2A isoform c

      Status: VALIDATED

      Source sequence(s)
      AC154597
      UniProtKB/Swiss-Prot
      Q9CYH2
      UniProtKB/TrEMBL
      D3Z252
      Conserved Domains (1) summary
      cd02970
      Location:37190
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
    12. NM_027464.4NP_081740.2  peroxiredoxin-like 2A isoform c

      See identical proteins and their annotated locations for NP_081740.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 6, 7, and 8 all encode the same isoform (c).
      Source sequence(s)
      AC154597, AI840708, AK017688, BB851890, CX238562
      Consensus CDS
      CCDS26957.1
      UniProtKB/Swiss-Prot
      Q9CYH2
      UniProtKB/TrEMBL
      D3Z252
      Related
      ENSMUSP00000022317.9, ENSMUST00000022317.15
      Conserved Domains (1) summary
      cd02970
      Location:37190
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      40715692..40735790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)