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    yuri yuri gagarin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34894, updated on 9-Dec-2024

    Summary

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    Official Symbol
    yuriprovided by FlyBase
    Official Full Name
    yuri gagarinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045842
    Locus tag
    Dmel_CG31732
    See related
    AllianceGenome:FB:FBgn0045842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS05639.1; BG:DS07851.11; CG11860; CG12635; CG31732; Dmel\CG31732; Yuri
    Summary
    Predicted to be a structural constituent of cytoskeleton. Involved in ciliary basal body organization; gravitaxis; and sperm individualization. Located in cytoplasm; investment cone; and nuclear envelope. Colocalizes with sarcoplasmic reticulum. Is expressed in several structures, including antennal nerve; embryonic/larval midgut primordium; gonad; male germline cell; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See yuri in Genome Data Viewer
    Location:
    35C5-35C5; 2-51 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15257267..15264692, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15257267..15264692, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene down and out Neighboring gene DNA polymerase delta subunit 3 Neighboring gene Uxt prefoldin-like subunit Neighboring gene Cullin 3 Neighboring gene UK114

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The proximal centriole-like structure maintains nucleus-centriole architecture in sperm. Buglak DB, et al. J Cell Sci, 2024 Sep 1. PMID 39166297, Free PMC Article
    2. The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis. Gilmutdinov R, et al. Development, 2021 Sep 1. PMID 34473243, Free PMC Article
    3. Functional dissection of the neural substrates for gravitaxic maze behavior in Drosophila melanogaster. Baker DA, et al. J Comp Neurol, 2007 Apr 10. PMID 17299758
    4. Yuri gagarin is required for actin, tubulin and basal body functions in Drosophila spermatogenesis. Texada MJ, et al. J Cell Sci, 2008 Jun 1. PMID 18477609
    5. salto/CG13164 is required for sperm head morphogenesis in Drosophila. Augière C, et al. Mol Biol Cell, 2019 Mar 1. PMID 30601696, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study identified Spag4 (previously named Giacomo) as a component of a centriolar-nuclear attachment pathway in spermatogenesis that also requires the coiled-coil protein Yuri and cytoplasmic dynein-dynactin
      Title: The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus.
    2. Yuri is a component of the motile actin cones that individualize the spermatids and is essential for their formation. Furthermore, Yuri is required for actin accumulation in the dense complex.
      Title: Yuri gagarin is required for actin, tubulin and basal body functions in Drosophila spermatogenesis.
    3. 18 candidate genes are now implicated in the gravitaxic behavior of flies. Yuri, located close to a known locus for gravitaxis, was studied more extensively by transgenic rescue.
      Title: Gravitaxis in Drosophila melanogaster: a forward genetic screen.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ciliary basal body organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gravitaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in investment cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    yuri gagarin
    Names
    CG31732-PB
    CG31732-PC
    CG31732-PD
    CG31732-PI
    CG31732-PN
    CG31732-PP
    CG31732-PR
    CG31732-PS
    yuri-PB
    yuri-PC
    yuri-PD
    yuri-PI
    yuri-PN
    yuri-PP
    yuri-PR
    yuri-PS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15257267..15264692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165106.5 → NP_723903.3  yuri gagarin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723903.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V435
      Conserved Domains (3) summary
      pfam15934
      Location:468 → 698
      Yuri_gagarin; Yuri gagarin
      cl00459
      Location:247 → 346
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl12013
      Location:598 → 736
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001038822.3 → NP_001033911.3  yuri gagarin, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033911.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDT6, Q2PDT8, Q8IHC0
      Conserved Domains (3) summary
      pfam15934
      Location:166 → 396
      Yuri_gagarin; Yuri gagarin
      cl12013
      Location:296 → 434
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19849
      Location:119 → 171
      DUF881; Bacterial protein of unknown function (DUF881)

    3. NM_001038821.2 → NP_001033910.2  yuri gagarin, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033910.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDT6, Q2PDT8, Q8IHC0
      Conserved Domains (3) summary
      pfam15934
      Location:166 → 396
      Yuri_gagarin; Yuri gagarin
      cl12013
      Location:296 → 434
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19849
      Location:119 → 171
      DUF881; Bacterial protein of unknown function (DUF881)

    4. NM_001316396.1 → NP_001303325.1  yuri gagarin, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0U1QT60
      Conserved Domains (1) summary
      cl12013
      Location:170 → 308
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. NM_001316397.1 → NP_001303326.1  yuri gagarin, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IP47, Q95R28
      Conserved Domains (1) summary
      cl00459
      Location:233 → 332
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    6. NM_165109.3 → NP_723906.1  yuri gagarin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IP47, Q95R28
      Related
      FBpp0080272
      Conserved Domains (1) summary
      cl00459
      Location:233 → 332
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    7. NM_165107.3 → NP_723904.1  yuri gagarin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PDT5, Q95R28, Q9VJP8
      Related
      FBpp0080271
      Conserved Domains (1) summary
      cl00459
      Location:247 → 346
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

    8. NM_001169512.1 → NP_001162983.1  yuri gagarin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K540
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0U1QT60 A0A0U1QT60
    Q2PDT6 Q2PDT6
    Q7K540 Q7K540
    Q8IHC0 Q8IHC0
    Q8IP47 Q8IP47
    Q95R28 Q95R28
    Q9V435 Q9V435
    Q9VJP8 Q9VJP8

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