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    MYRF myelin regulatory factor [ Homo sapiens (human) ]

    Gene ID: 745, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MYRFprovided by HGNC
    Official Full Name
    myelin regulatory factorprovided by HGNC
    Primary source
    HGNC:HGNC:1181
    See related
    Ensembl:ENSG00000124920 MIM:608329; AllianceGenome:HGNC:1181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRF; CUGS; MMERV; Ndt80; 11orf9; pqn-47; C11orf9
    Summary
    This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Expression
    Biased expression in stomach (RPKM 32.1), brain (RPKM 26.8) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYRF in Genome Data Viewer
    Location:
    11q12.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61752636..61788518)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61741556..61777435)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61520108..61555990)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61393636-61394198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61394199-61394759 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 3465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61396115-61397096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61406067-61406567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61406607-61407134 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61408188-61408713 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:61430561-61431253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61450060-61450734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61450735-61451408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61457781-61458312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61458313-61458844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61462250-61462775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61462776-61463302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61463303-61463829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61465411-61465936 Neighboring gene diacylglycerol lipase alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61465937-61466463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61466990-61467516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61467517-61468042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61468570-61469095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61482486-61483272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61483273-61484058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61484845-61485630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61485631-61486417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61486418-61487203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61487991-61488775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61507907-61508480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61514637-61515498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61516359-61517220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3398 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:61523524-61524723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61524877-61525520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61528511-61529267 Neighboring gene MYRF antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61535574-61536150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61536151-61536726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61546818-61547486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61548157-61548825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61552558-61553302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61553303-61554047 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:61559319-61560296 and GRCh37_chr11:61560297-61561272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61562818-61563318 Neighboring gene transmembrane protein 258 Neighboring gene microRNA 611 Neighboring gene flap structure-specific endonuclease 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional mechanisms of MYRF DNA-binding domain mutations implicated in birth defects. Fan C, et al. J Biol Chem, 2021 Jan-Jun. PMID 33798553, Free PMC Article
    2. MYRF haploinsufficiency causes 46,XY and 46,XX disorders of sex development: bioinformatics consideration. Hamanaka K, et al. Hum Mol Genet, 2019 Jul 15. PMID 30985895
    3. Review of the phenotypic spectrum associated with haploinsufficiency of MYRF. Rossetti LZ, et al. Am J Med Genet A, 2019 Jul. PMID 31069960, Free PMC Article
    4. De novo variants in Myelin regulatory factor (MYRF) as candidates of a new syndrome of cardiac and urogenital anomalies. Pinz H, et al. Am J Med Genet A, 2018 Apr. PMID 29446546, Free PMC Article
    5. Autosomal dominant nanophthalmos and high hyperopia associated with a C-terminal frameshift variant in MYRF. Siggs OM, et al. Mol Vis, 2019. PMID 31700225, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two sisters with cardiac-urogenital syndrome secondary to pathogenic splicing variant in the MYRF gene with unaffected parents: A case of gonadal mosaicism?
      Title: Two sisters with cardiac-urogenital syndrome secondary to pathogenic splicing variant in the MYRF gene with unaffected parents: A case of gonadal mosaicism?
    2. Truncation mutations in MYRF underlie primary angle closure glaucoma.
      Title: Truncation mutations in MYRF underlie primary angle closure glaucoma.
    3. Evaluation of MYRF as a candidate gene for primary angle closure glaucoma.
      Title: Evaluation of MYRF as a candidate gene for primary angle closure glaucoma.
    4. Functional mechanisms of MYRF DNA-binding domain mutations implicated in birth defects.
      Title: Functional mechanisms of MYRF DNA-binding domain mutations implicated in birth defects.
    5. MYRF: A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases.
      Title: MYRF: A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases.
    6. Common Myelin Regulatory Factor Gene Variants Predisposing to Excellence in Sports.
      Title: Common Myelin Regulatory Factor Gene Variants Predisposing to Excellence in Sports.
    7. The genetic and clinical landscape of nanophthalmos and posterior microphthalmos in an Australian cohort.
      Title: The genetic and clinical landscape of nanophthalmos and posterior microphthalmos in an Australian cohort.
    8. Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis.
      Title: Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis.
    9. Functional mechanism and pathogenic potential of MYRF ICA domain mutations implicated in birth defects.
      Title: Functional mechanism and pathogenic potential of MYRF ICA domain mutations implicated in birth defects.
    10. results underline the importance of including SLC18A3 sequencing in the differential diagnostics of fetuses with arthrogryposis, FADS, or LMPS of unknown etiology
      Title: Review of the phenotypic spectrum associated with haploinsufficiency of MYRF.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
    EBI GWAS Catalog
    Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of chromosome 11 open reading frame 9 (C11orf9) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0954, MGC10781

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system myelin maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system myelin maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in central nervous system myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oligodendrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oligodendrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autoprocessing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoprocessing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    myelin regulatory factor
    Names
    myelin gene regulatory factor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047038.1 RefSeqGene

      Range
      5000..40882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001127392.3 → NP_001120864.1  myelin regulatory factor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001120864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 5' exon and uses an alternate 5' terminal exon, compared to variant 1. It encodes isoform 2 which is longer and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB023171, AI366703, AP002380, HY145048, HY148147
      Consensus CDS
      CCDS44622.1
      UniProtKB/Swiss-Prot
      O43582, Q9P1Q6, Q9Y2G1
      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Related
      ENSP00000278836.4, ENST00000278836.10
      Conserved Domains (4) summary
      pfam05224
      Location:393 → 540
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:587 → 647
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:667 → 702
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:1016 → 1147
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    2. NM_013279.4 → NP_037411.1  myelin regulatory factor isoform 1

      See identical proteins and their annotated locations for NP_037411.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB023171, AF086762, AI366703, AP002380
      Consensus CDS
      CCDS31579.1
      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Related
      ENSP00000265460.5, ENST00000265460.9
      Conserved Domains (4) summary
      pfam05224
      Location:384 → 531
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:578 → 638
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:658 → 693
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:976 → 1107
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      61752636..61788518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274222.2 → XP_005274279.1  myelin regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Conserved Domains (4) summary
      pfam05224
      Location:393 → 540
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:587 → 647
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:667 → 702
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:1017 → 1148
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    2. XM_005274223.2 → XP_005274280.1  myelin regulatory factor isoform X2

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Conserved Domains (4) summary
      pfam05224
      Location:393 → 540
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:587 → 647
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:667 → 702
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:1012 → 1143
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    3. XM_005274224.2 → XP_005274281.1  myelin regulatory factor isoform X3

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Conserved Domains (4) summary
      pfam05224
      Location:393 → 540
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:587 → 647
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:667 → 702
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:1011 → 1142
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    4. XM_005274225.2 → XP_005274282.1  myelin regulatory factor isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Conserved Domains (4) summary
      pfam05224
      Location:393 → 540
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:587 → 647
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:667 → 702
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:990 → 1121
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    5. XM_005274227.2 → XP_005274284.1  myelin regulatory factor isoform X6

      See identical proteins and their annotated locations for XP_005274284.1

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Conserved Domains (4) summary
      pfam05224
      Location:393 → 540
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:587 → 647
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:667 → 702
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:985 → 1116
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    6. XM_005274226.2 → XP_005274283.1  myelin regulatory factor isoform X5

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Conserved Domains (4) summary
      pfam05224
      Location:393 → 540
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:587 → 647
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:667 → 702
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:989 → 1120
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    7. XM_047427526.1 → XP_047283482.1  myelin regulatory factor isoform X7

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    8. XM_005274228.2 → XP_005274285.1  myelin regulatory factor isoform X8

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Conserved Domains (4) summary
      pfam05224
      Location:342 → 489
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:536 → 596
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:616 → 651
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:966 → 1097
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    9. XM_047427528.1 → XP_047283484.1  myelin regulatory factor isoform X10

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    10. XM_047427527.1 → XP_047283483.1  myelin regulatory factor isoform X9

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    11. XM_047427529.1 → XP_047283485.1  myelin regulatory factor isoform X11

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    12. XM_047427531.1 → XP_047283487.1  myelin regulatory factor isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    13. XM_047427533.1 → XP_047283489.1  myelin regulatory factor isoform X15

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    14. XM_047427532.1 → XP_047283488.1  myelin regulatory factor isoform X14

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    15. XM_047427534.1 → XP_047283490.1  myelin regulatory factor isoform X16

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    16. XM_047427530.1 → XP_047283486.1  myelin regulatory factor isoform X12

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    17. XM_047427535.1 → XP_047283491.1  myelin regulatory factor isoform X17

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    18. XM_024448677.2 → XP_024304445.1  myelin regulatory factor isoform X18

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Conserved Domains (4) summary
      pfam05224
      Location:246 → 393
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:440 → 500
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:520 → 555
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:870 → 1001
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    19. XM_047427536.1 → XP_047283492.1  myelin regulatory factor isoform X19

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    20. XM_047427537.1 → XP_047283493.1  myelin regulatory factor isoform X20

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    21. XM_047427538.1 → XP_047283494.1  myelin regulatory factor isoform X21

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    22. XM_011545234.3 → XP_011543536.1  myelin regulatory factor isoform X22

      UniProtKB/TrEMBL
      A0A6Q8PHM1
      Related
      ENSP00000502795.1, ENST00000675319.1
      Conserved Domains (4) summary
      pfam05224
      Location:192 → 339
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:386 → 446
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:466 → 501
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:816 → 947
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      61741556..61777435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369829.1 → XP_054225804.1  myelin regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    2. XM_054369830.1 → XP_054225805.1  myelin regulatory factor isoform X2

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    3. XM_054369831.1 → XP_054225806.1  myelin regulatory factor isoform X3

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    4. XM_054369832.1 → XP_054225807.1  myelin regulatory factor isoform X4

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    5. XM_054369834.1 → XP_054225809.1  myelin regulatory factor isoform X6

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    6. XM_054369833.1 → XP_054225808.1  myelin regulatory factor isoform X5

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    7. XM_054369835.1 → XP_054225810.1  myelin regulatory factor isoform X7

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    8. XM_054369836.1 → XP_054225811.1  myelin regulatory factor isoform X8

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    9. XM_054369838.1 → XP_054225813.1  myelin regulatory factor isoform X10

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    10. XM_054369837.1 → XP_054225812.1  myelin regulatory factor isoform X9

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    11. XM_054369839.1 → XP_054225814.1  myelin regulatory factor isoform X11

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    12. XM_054369841.1 → XP_054225816.1  myelin regulatory factor isoform X13

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    13. XM_054369843.1 → XP_054225818.1  myelin regulatory factor isoform X15

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    14. XM_054369842.1 → XP_054225817.1  myelin regulatory factor isoform X14

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    15. XM_054369844.1 → XP_054225819.1  myelin regulatory factor isoform X16

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    16. XM_054369840.1 → XP_054225815.1  myelin regulatory factor isoform X12

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    17. XM_054369845.1 → XP_054225820.1  myelin regulatory factor isoform X17

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    18. XM_054369850.1 → XP_054225825.1  myelin regulatory factor isoform X22

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    19. XM_054369846.1 → XP_054225821.1  myelin regulatory factor isoform X18

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    20. XM_054369847.1 → XP_054225822.1  myelin regulatory factor isoform X19

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    21. XM_054369848.1 → XP_054225823.1  myelin regulatory factor isoform X20

      UniProtKB/TrEMBL
      A0A6Q8PHM1

    22. XM_054369849.1 → XP_054225824.1  myelin regulatory factor isoform X21

      UniProtKB/TrEMBL
      A0A6Q8PHM1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2G1.3 GenPept UniProtKB/Swiss-Prot:Q9Y2G1

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