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    RIN2 Ras and Rab interactor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 477139, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RIN2provided by VGNC
    Official Full Name
    Ras and Rab interactor 2provided by VGNC
    Primary source
    VGNC:VGNC:45587
    See related
    Ensembl:ENSCAFG00845029255
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See RIN2 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 24 NC_051828.1 (3753523..3972256, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 24 NC_006606.4 (3373428..3591885, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 24 NC_049245.1 (3730425..3949191, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 24 NC_049284.1 (3349198..3567538, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 24 NC_049765.1 (3452567..3671029, complement)

    Chromosome 24 - NC_051828.1Genomic Context describing neighboring genes Neighboring gene proline rich 3 pseudogene Neighboring gene N-alpha-acetyltransferase 20, NatB catalytic subunit Neighboring gene uncharacterized LOC111092136 Neighboring gene uncharacterized LOC119865611 Neighboring gene uncharacterized LOC119865613 Neighboring gene solute carrier family 24 member 3 Neighboring gene uncharacterized LOC111092176

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras and Rab interactor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051828.1 Reference ROS_Cfam_1.0

      Range
      3753523..3972256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038432985.1 → XP_038288913.1  ras and Rab interactor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LZ64, A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:661 → 779
      VPS9; Domain present in VPS9
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:800 → 890
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    2. XM_038432990.1 → XP_038288918.1  ras and Rab interactor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LV04, A0A8C0TLN7, A0A8C0TNT8
      Conserved Domains (3) summary
      smart00167
      Location:616 → 734
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:755 → 845
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    3. XM_038432989.1 → XP_038288917.1  ras and Rab interactor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LV04, A0A8C0TLN7, A0A8C0TNT8
      Conserved Domains (3) summary
      smart00167
      Location:616 → 734
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:755 → 845
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    4. XM_038432991.1 → XP_038288919.1  ras and Rab interactor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8C0TLN7
      Conserved Domains (3) summary
      smart00167
      Location:608 → 726
      VPS9; Domain present in VPS9
      cd10394
      Location:33 → 132
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:747 → 837
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    5. XM_038432992.1 → XP_038288920.1  ras and Rab interactor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8C0TLN7
      Conserved Domains (3) summary
      smart00167
      Location:608 → 726
      VPS9; Domain present in VPS9
      cd10394
      Location:33 → 132
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:747 → 837
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    6. XM_038432987.1 → XP_038288915.1  ras and Rab interactor 2 isoform X7

      UniProtKB/TrEMBL
      A0A8C0TNS3
      Conserved Domains (3) summary
      smart00167
      Location:629 → 747
      VPS9; Domain present in VPS9
      cd16131
      Location:768 → 858
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
      cl15255
      Location:122 → 155
      SH2; Src homology 2 (SH2) domain

    7. XM_038432986.1 → XP_038288914.1  ras and Rab interactor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8C0TNS3
      Conserved Domains (3) summary
      smart00167
      Location:648 → 766
      VPS9; Domain present in VPS9
      cd16131
      Location:787 → 877
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
      cl15255
      Location:122 → 215
      SH2; Src homology 2 (SH2) domain

    8. XM_038432982.1 → XP_038288910.1  ras and Rab interactor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0Z5S2, A0A8I3QJ76
      Related
      ENSCAFP00845040685.1, ENSCAFT00845051853.1
      Conserved Domains (3) summary
      smart00167
      Location:697 → 815
      VPS9; Domain present in VPS9
      cd10394
      Location:122 → 221
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:836 → 926
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    9. XM_038432988.1 → XP_038288916.1  ras and Rab interactor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0TLN7, A0A8I3QJ40
      Related
      ENSCAFP00845040625.1, ENSCAFT00845051778.1
      Conserved Domains (3) summary
      smart00167
      Location:627 → 745
      VPS9; Domain present in VPS9
      cd10394
      Location:52 → 151
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:766 → 856
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    10. XM_038432983.1 → XP_038288911.1  ras and Rab interactor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:692 → 810
      VPS9; Domain present in VPS9
      cd10394
      Location:117 → 216
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:831 → 921
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    11. XM_038432984.1 → XP_038288912.1  ras and Rab interactor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0Z5S2
      Related
      ENSCAFP00845040608.1, ENSCAFT00845051758.1
      Conserved Domains (3) summary
      smart00167
      Location:692 → 810
      VPS9; Domain present in VPS9
      cd10394
      Location:117 → 216
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:831 → 921
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049284.1 Alternate UMICH_Zoey_3.1

      Range
      3349198..3567538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038508200.1 → XP_038364128.1  ras and Rab interactor 2 isoform X1

      Conserved Domains (3) summary
      smart00167
      Location:661 → 779
      VPS9; Domain present in VPS9
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:800 → 890
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    2. XM_038508205.1 → XP_038364133.1  ras and Rab interactor 2 isoform X3

      Conserved Domains (3) summary
      smart00167
      Location:616 → 734
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:755 → 845
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    3. XM_038508204.1 → XP_038364132.1  ras and Rab interactor 2 isoform X3

      Conserved Domains (3) summary
      smart00167
      Location:616 → 734
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:755 → 845
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    4. XM_038508201.1 → XP_038364129.1  ras and Rab interactor 2 isoform X11

    5. XM_038508202.1 → XP_038364130.1  ras and Rab interactor 2 isoform X12

    6. XM_038508197.1 → XP_038364125.1  ras and Rab interactor 2 isoform X9

    7. XM_038508198.1 → XP_038364126.1  ras and Rab interactor 2 isoform X9

    8. XM_038508199.1 → XP_038364127.1  ras and Rab interactor 2 isoform X10

    9. XM_038508203.1 → XP_038364131.1  ras and Rab interactor 2 isoform X2

      Conserved Domains (3) summary
      smart00167
      Location:627 → 745
      VPS9; Domain present in VPS9
      cd10394
      Location:52 → 151
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:766 → 856
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049765.1 Alternate UNSW_CanFamBas_1.0

      Range
      3452567..3671029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038635692.1 → XP_038491620.1  ras and Rab interactor 2 isoform X1

    2. XM_038635698.1 → XP_038491626.1  ras and Rab interactor 2 isoform X3

    3. XM_038635697.1 → XP_038491625.1  ras and Rab interactor 2 isoform X3

    4. XM_038635694.1 → XP_038491622.1  ras and Rab interactor 2 isoform X14

    5. XM_038635690.1 → XP_038491618.1  ras and Rab interactor 2 isoform X13

    6. XM_038635691.1 → XP_038491619.1  ras and Rab interactor 2 isoform X13

    7. XM_038635693.1 → XP_038491621.1  ras and Rab interactor 2 isoform X1

    8. XM_038635695.1 → XP_038491623.1  ras and Rab interactor 2 isoform X2

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049245.1 Alternate UU_Cfam_GSD_1.0

      Range
      3730425..3949191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038571454.1 → XP_038427382.1  ras and Rab interactor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LZ64, A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:661 → 779
      VPS9; Domain present in VPS9
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:800 → 890
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    2. XM_038571459.1 → XP_038427387.1  ras and Rab interactor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LV04, A0A8C0TLN7, A0A8C0TNT8
      Conserved Domains (3) summary
      smart00167
      Location:616 → 734
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:755 → 845
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    3. XM_038571458.1 → XP_038427386.1  ras and Rab interactor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LV04, A0A8C0TLN7, A0A8C0TNT8
      Conserved Domains (3) summary
      smart00167
      Location:616 → 734
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:755 → 845
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    4. XM_038571456.1 → XP_038427384.1  ras and Rab interactor 2 isoform X16

      UniProtKB/TrEMBL
      A0A8C0PQS2

    5. XM_038571452.1 → XP_038427380.1  ras and Rab interactor 2 isoform X15

      UniProtKB/TrEMBL
      A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:699 → 817
      VPS9; Domain present in VPS9
      cd10394
      Location:124 → 223
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:838 → 928
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    6. XM_038571453.1 → XP_038427381.1  ras and Rab interactor 2 isoform X15

      UniProtKB/TrEMBL
      A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:699 → 817
      VPS9; Domain present in VPS9
      cd10394
      Location:124 → 223
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:838 → 928
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    7. XM_038571455.1 → XP_038427383.1  ras and Rab interactor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LZ64, A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:661 → 779
      VPS9; Domain present in VPS9
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:800 → 890
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    8. XM_038571457.1 → XP_038427385.1  ras and Rab interactor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0TLN7, A0A8I3QJ40
      Conserved Domains (3) summary
      smart00167
      Location:627 → 745
      VPS9; Domain present in VPS9
      cd10394
      Location:52 → 151
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:766 → 856
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006606.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      3373428..3591885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005634722.4 → XP_005634779.1  ras and Rab interactor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LZ64, A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:661 → 779
      VPS9; Domain present in VPS9
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:800 → 890
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    2. XM_038458132.1 → XP_038314060.1  ras and Rab interactor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LV04, A0A8C0TLN7, A0A8C0TNT8
      Conserved Domains (3) summary
      smart00167
      Location:616 → 734
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:755 → 845
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    3. XM_038458131.1 → XP_038314059.1  ras and Rab interactor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0LV04, A0A8C0TLN7, A0A8C0TNT8
      Conserved Domains (3) summary
      smart00167
      Location:616 → 734
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:755 → 845
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    4. XM_014106942.3 → XP_013962417.1  ras and Rab interactor 2 isoform X18

      UniProtKB/TrEMBL
      A0A8C0PQS2
      Conserved Domains (3) summary
      smart00167
      Location:631 → 749
      VPS9; Domain present in VPS9
      cd01776
      Location:773 → 859
      Rin1_RA; Ubiquitin domain of RIN1 RAS effector
      cl15255
      Location:124 → 157
      SH2; Src homology 2 (SH2) domain

    5. XM_005634721.4 → XP_005634778.1  ras and Rab interactor 2 isoform X17

      UniProtKB/TrEMBL
      A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:699 → 817
      VPS9; Domain present in VPS9
      cd10394
      Location:124 → 223
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:838 → 928
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    6. XM_038458129.1 → XP_038314057.1  ras and Rab interactor 2 isoform X17

      UniProtKB/TrEMBL
      A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:699 → 817
      VPS9; Domain present in VPS9
      cd10394
      Location:124 → 223
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:838 → 928
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    7. XM_038458130.1 → XP_038314058.1  ras and Rab interactor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0LZ64, A0A8C0Z5S2
      Conserved Domains (3) summary
      smart00167
      Location:661 → 779
      VPS9; Domain present in VPS9
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:800 → 890
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    8. XM_022409239.2 → XP_022264947.1  ras and Rab interactor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0TLN7, A0A8I3QJ40
      Conserved Domains (3) summary
      smart00167
      Location:627 → 745
      VPS9; Domain present in VPS9
      cd10394
      Location:52 → 151
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:766 → 856
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
    Nucleotide Protein
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