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    mink1 misshapen-like kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100038799, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mink1provided by ZNC
    Official Full Name
    misshapen-like kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060526-45
    See related
    Ensembl:ENSDARG00000035360 AllianceGenome:ZFIN:ZDB-GENE-060526-45
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    msn3; zgc:162163; si:ch211-147a23.2
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See mink1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (38301906..38385380, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37701753..37785380, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain-containing protein 5B Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 2 Neighboring gene uncharacterized LOC137490148 Neighboring gene phospholipase D2 Neighboring gene cholinergic receptor, nicotinic, epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Köppen M, et al. Development, 2006 Jul. PMID 16794032
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    misshapen-like kinase 1
    NP_001083048.2
    NP_001300770.1
    XP_017211494.1
    XP_017211495.1
    XP_017211497.1
    XP_017211499.1
    XP_021331645.1
    XP_021331646.1
    XP_021331647.1
    XP_021331648.1
    XP_068077151.1
    XP_068077152.1
    XP_068077153.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089579.2 → NP_001083048.2  misshapen-like kinase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BX324194
      UniProtKB/TrEMBL
      A0A8M1NDD4, F1REC7
      Related
      ENSDARP00000051232.5, ENSDART00000051233.5
      Conserved Domains (1) summary
      cl21453
      Location:8 → 139
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001313841.1 → NP_001300770.1  misshapen-like kinase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX324194
      UniProtKB/TrEMBL
      A0A2R8QM71, A0A8M1P738
      Related
      ENSDARP00000156553.1, ENSDART00000188573.1
      Conserved Domains (3) summary
      smart00036
      Location:955 → 1253
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:25 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      38301906..38385380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017356008.3 → XP_017211497.1  misshapen-like kinase 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M6YYZ8
      Related
      ENSDARP00000113008.1, ENSDART00000135260.3

    2. XM_017356010.3 → XP_017211499.1  misshapen-like kinase 1 isoform X10

      UniProtKB/TrEMBL
      A0A8M6Z0G7

    3. XM_068221052.1 → XP_068077153.1  misshapen-like kinase 1 isoform X11

    4. XM_068221051.1 → XP_068077152.1  misshapen-like kinase 1 isoform X9

    5. XM_017356006.3 → XP_017211495.1  misshapen-like kinase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M6Z686

    6. XM_017356005.3 → XP_017211494.1  misshapen-like kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M6YY39

    7. XM_068221050.1 → XP_068077151.1  misshapen-like kinase 1 isoform X8

    8. XM_021475973.2 → XP_021331648.1  misshapen-like kinase 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9PX03
      Conserved Domains (2) summary
      smart00036
      Location:960 → 1258
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    9. XM_021475971.2 → XP_021331646.1  misshapen-like kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q813
      Conserved Domains (2) summary
      smart00036
      Location:994 → 1292
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    10. XM_021475972.2 → XP_021331647.1  misshapen-like kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PJK9
      Conserved Domains (2) summary
      smart00036
      Location:988 → 1286
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    11. XM_021475970.2 → XP_021331645.1  misshapen-like kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QDG2
      Conserved Domains (2) summary
      smart00036
      Location:996 → 1294
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06636
      Location:8 → 289
      STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394597.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      37049..119898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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