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    tle3a TLE family member 3, transcriptional corepressor a [ Danio rerio (zebrafish) ]

    Gene ID: 30206, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tle3aprovided by ZNC
    Official Full Name
    TLE family member 3, transcriptional corepressor aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-86
    See related
    Ensembl:ENSDARG00000002787 AllianceGenome:ZFIN:ZDB-GENE-990415-86
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    grg2; gro2; groucho2; sb:eu295; sb:eu753
    Summary
    Predicted to enable transcription corepressor activity. Acts upstream of or within regulation of retinoic acid biosynthetic process and sclerotome development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including axis; central nervous system; mesoderm; oocyte; and unfertilized egg. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tle3a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (20225919..20257520)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (20236846..20268454)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 1 Neighboring gene uveal autoantigen with coiled-coil domains and ankyrin repeats a Neighboring gene kinesin family member 23 Neighboring gene progestin and adipoQ receptor family member Va

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish mitotic kinesin-like protein 1 (Mklp1) functions in embryonic cytokinesis. Chen MC, et al. Physiol Genomics, 2002 Feb 11. PMID 11842131
    2. Two zebrafish homologues of the Drosophila neurogenic gene groucho and their pattern of transcription during early embryogenesis. Wülbeck C, et al. Dev Genes Evol, 1997 Aug. PMID 27747413
    3. Evolution of the Groucho/Tle gene family: gene organization and duplication events. Bajoghli B. Dev Genes Evol, 2007 Aug. PMID 17624551
    4. Duplicated members of the Groucho/Tle gene family in fish. Aghaallaei N, et al. Dev Dyn, 2005 Sep. PMID 16059907
    5. her1, a zebrafish pair-rule like gene, acts downstream of notch signalling to control somite development. Takke C, et al. Development, 1999 Jul. PMID 10357943

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of retinoic acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sclerotome development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 3-A
    Names
    groucho-related Grg2
    groucho-related protein grg2
    protein groucho-2
    transducin-like enhancer of split 3a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313694.1 → NP_001300623.1  transducin-like enhancer protein 3-A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX324138, CT613405, EH525475
      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M2B5H4, B3DGV3, E7F3V0
      Related
      ENSDARP00000091405.4, ENSDART00000100632.4
      Conserved Domains (5) summary
      COG2319
      Location:468 → 760
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:474 → 759
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam15719
      Location:290 → 335
      DUF4674; Domain of unknown function (DUF4674)
      sd00039
      Location:479 → 518
      7WD40; WD40 repeat [structural motif]

    2. NM_131012.2 → NP_571087.2  transducin-like enhancer protein 3-A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in its 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BX324138, CT613405, EH525475
      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M2B607
      Conserved Domains (5) summary
      COG2319
      Location:467 → 759
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:473 → 758
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 142
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam15719
      Location:289 → 334
      DUF4674; Domain of unknown function (DUF4674)
      sd00039
      Location:478 → 517
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      20225919..20257520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159039.5 → XP_005159096.1  transducin-like enhancer protein 3-A isoform X1

      See identical proteins and their annotated locations for XP_005159096.1

      UniProtKB/Swiss-Prot
      O13166
      UniProtKB/TrEMBL
      A0A8M2B5H4, B3DGV3, E7F3V0
      Related
      ENSDARP00000045678.7, ENSDART00000045679.9
      Conserved Domains (5) summary
      COG2319
      Location:468 → 760
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:474 → 759
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      pfam15719
      Location:290 → 335
      DUF4674; Domain of unknown function (DUF4674)
      sd00039
      Location:479 → 518
      7WD40; WD40 repeat [structural motif]

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395339.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      231350..261261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O13166.1 GenPept UniProtKB/Swiss-Prot:O13166

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