xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: xrcc1provided by ZNC
Official Full Name: X-ray repair complementing defective repair in Chinese hamster cells 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040822-30
See related: Ensembl:ENSDARG00000009494 AllianceGenome:ZFIN:ZDB-GENE-040822-30
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91996
Summary: Predicted to enable damaged DNA binding activity. Predicted to be involved in base-excision repair. Predicted to act upstream of or within double-strand break repair via nonhomologous end joining and single strand break repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); central nervous system cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (54209437..54246193)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (54350982..54387738)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in base-excision repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within base-excision repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within single strand break repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA repair protein XRCC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003988.2 → NP_001003988.2 DNA repair protein XRCC1

Status: VALIDATED

Source sequence(s)

BC080268, CU655846, CU694200, EH437540

UniProtKB/TrEMBL

A0A0R4IBN8, A0A8M1N1V3, F1QXI2, Q68EG6

Related

ENSDARP00000023168.5, ENSDART00000020033.8

Conserved Domains (3) summary

smart00292
Location:526 → 600

BRCT; breast cancer carboxy-terminal domain

pfam00533
Location:319 → 393

BRCT; BRCA1 C Terminus (BRCT) domain

pfam01834
Location:1 → 147

XRCC1_N; XRCC1 N terminal domain