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    dnsn-1 Downstream Neighbor of SoN homolog [ Caenorhabditis elegans ]

    Gene ID: 173431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dnsn-1
    Official Full Name
    Downstream Neighbor of SoN homolog
    Primary source
    WormBase:WBGene00016074
    Locus tag
    CELE_C24H12.5
    See related
    AllianceGenome:WB:WBGene00016074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in nuclear DNA replication. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in microcephaly, short stature, and limb abnormalities and microcephaly-micromelia syndrome. Orthologous to human DONSON (DNA replication fork stabilization factor DONSON). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dnsn-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (406137..410932, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene C-type LECtin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Helicase C-terminal domain-containing protein;RNA helicase Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans. Nordquist SK, et al. G3 (Bethesda), 2018 Mar 2. PMID 29367452, Free PMC Article
    2. DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans. Xia Y, et al. Science, 2023 Sep 22. PMID 37590372, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans.
      Title: DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in nuclear DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Downstream Neighbor of SoN homolog
    NP_001254011.1
    • Product from WormBase gene class dnsn;
      Confirmed by transcript evidence
    NP_001300517.1
    • Product from WormBase gene class dnsn;
      Confirmed by transcript evidence
    NP_001300518.1
    • Product from WormBase gene class dnsn;
      Confirmed by transcript evidence
    NP_493726.2
    • Product from WormBase gene class dnsn;
      Confirmed by transcript evidence
    NP_493727.2
    • Product from WormBase gene class dnsn;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      406137..410932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061326.7 → NP_493727.2  Downstream Neighbor of SoN homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYF1

    2. NM_061325.6 → NP_493726.2  Downstream Neighbor of SoN homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493726.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95X82

    3. NM_001267082.4 → NP_001254011.1  Downstream Neighbor of SoN homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1ZUV7

    4. NM_001313588.3 → NP_001300517.1  Downstream Neighbor of SoN homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AWU0

    5. NM_001313589.3 → NP_001300518.1  Downstream Neighbor of SoN homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARI1
    Nucleotide Protein
    Heading Accession and Version

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