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    ttc8 tetratricopeptide repeat domain 8 [ Danio rerio (zebrafish) ]

    Gene ID: 678551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttc8provided by ZNC
    Official Full Name
    tetratricopeptide repeat domain 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8846
    See related
    Ensembl:ENSDARG00000099481 AllianceGenome:ZFIN:ZDB-GENE-030131-8846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bbs8; fk26c02; wu:fk26c02; zgc:136718
    Summary
    Acts upstream of or within several processes, including Kupffer's vesicle development; embryonic morphogenesis; and establishment of pigment granule localization. Predicted to be part of BBSome. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See ttc8 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003335638.2 (12..3620, complement)
    RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_008805388.1 (1..958, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003335638.2 (12..3620, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_008805388.1 (1..958, complement)

    NW_003335638.2Genomic Context describing neighboring genes

    NW_008805388.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish. May-Simera HL, et al. Dev Biol, 2010 Sep 15. PMID 20643117
    2. Bardet-Biedl syndrome: an emerging pathomechanism of intracellular transport. Blacque OE, et al. Cell Mol Life Sci, 2006 Sep. PMID 16909204, Free PMC Article
    3. The intraflagellar transport protein ift80 is essential for photoreceptor survival in a zebrafish model of jeune asphyxiating thoracic dystrophy. Hudak LM, et al. Invest Ophthalmol Vis Sci, 2010 Jul. PMID 20207966, Free PMC Article
    4. Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet-Biedl syndrome. Tobin JL, et al. Proc Natl Acad Sci U S A, 2008 May 6. PMID 18443298, Free PMC Article
    5. Genetic interaction between Bardet-Biedl syndrome genes and implications for limb patterning. Tayeh MK, et al. Hum Mol Genet, 2008 Jul 1. PMID 18381349, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish
      Title: Bbs8, together with the planar cell polarity protein Vangl2, is required to establish left-right asymmetry in zebrafish.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136718

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within left/right pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within left/right pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within melanosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within otolith development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within otolith development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pigment granule aggregation in cell center IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BBSome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BBSome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in non-motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040309.1 → NP_001035399.1  tetratricopeptide repeat protein 8

      See identical proteins and their annotated locations for NP_001035399.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115238
      UniProtKB/TrEMBL
      Q1RLX7
      Related
      ENSDARP00000140172.2, ENSDART00000165981.2
      Conserved Domains (3) summary
      COG0457
      Location:216 → 499
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:352 → 380
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:353 → 381
      TPR_1; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NW_003335638.2 Reference GRCz11 Primary Assembly

      Range
      12..3620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 Primary Assembly

    Genomic

    1. NW_008805388.1 Reference GRCz11 Primary Assembly

      Range
      1..958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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