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    Chek2 checkpoint kinase 2 [ Chinchilla lanigera (long-tailed chinchilla) ]

    Gene ID: 102022254, updated on 16-Nov-2024

    Summary

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    Gene symbol
    Chek2
    Gene description
    checkpoint kinase 2
    See related
    Ensembl:ENSCLAG00000013905 RGD:8851058
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Chinchilla lanigera
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Chinchillidae; Chinchilla
    Orthologs
    human mouse all
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    Genomic context

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    See Chek2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    101 current ChiLan1.0 (GCF_000276665.1) Unplaced Scaffold NW_004955455.1 (2969113..3008004, complement)

    NW_004955455.1Genomic Context describing neighboring genes Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene coiled-coil domain containing 117 Neighboring gene HscB mitochondrial iron-sulfur cluster cochaperone Neighboring gene X-box binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_004955455.1 Unplaced Scaffold Reference ChiLan1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Chk2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Chinchilla lanigera Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ChiLan1.0 Primary Assembly

    Genomic

    1. NW_004955455.1 Reference ChiLan1.0 Primary Assembly

      Range
      2969113..3008004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_013520376.1 → XP_013375830.1  serine/threonine-protein kinase Chk2 isoform X4

      UniProtKB/TrEMBL
      A0A8C2VTG3
      Related
      ENSCLAP00000020299.1, ENSCLAT00000020495.1
      Conserved Domains (3) summary
      smart00220
      Location:237 → 504
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:110 → 218
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:230 → 504
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    2. XM_005396164.2 → XP_005396221.1  serine/threonine-protein kinase Chk2 isoform X2

      UniProtKB/TrEMBL
      A0A8C2VTG3
      Conserved Domains (3) summary
      smart00220
      Location:304 → 571
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:177 → 285
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:297 → 571
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    3. XM_013520375.1 → XP_013375829.1  serine/threonine-protein kinase Chk2 isoform X3

      UniProtKB/TrEMBL
      A0A8C2VTG3
      Conserved Domains (3) summary
      smart00220
      Location:314 → 563
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:187 → 295
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:307 → 563
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    4. XM_013520374.1 → XP_013375828.1  serine/threonine-protein kinase Chk2 isoform X1

      UniProtKB/TrEMBL
      A0A8C2VTG3
      Conserved Domains (3) summary
      smart00220
      Location:314 → 581
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:187 → 295
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:307 → 581
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    5. XM_013520379.1 → XP_013375833.1  serine/threonine-protein kinase Chk2 isoform X7

      Conserved Domains (2) summary
      smart00220
      Location:71 → 338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14084
      Location:64 → 338
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    6. XM_013520378.1 → XP_013375832.1  serine/threonine-protein kinase Chk2 isoform X6

      Conserved Domains (3) summary
      smart00220
      Location:162 → 429
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:53 → 143
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd14084
      Location:155 → 429
      STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

    7. XM_013520377.1 → XP_013375831.1  serine/threonine-protein kinase Chk2 isoform X5

      Conserved Domains (3) summary
      smart00220
      Location:314 → 515
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00060
      Location:187 → 295
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl21453
      Location:307 → 544
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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