Ring1 ring finger protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ring1provided by RGD
Official Full Name: ring finger protein 1provided by RGD
Primary source: RGD:3576
See related: EnsemblRapid:ENSRNOG00000000467 AllianceGenome:RGD:3576
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ring1A
Summary: Predicted to enable chromatin binding activity; ubiquitin protein ligase activity; and ubiquitin-protein transferase activator activity. Predicted to be involved in chromatin remodeling and negative regulation of DNA-templated transcription. Predicted to act upstream of or within with a positive effect on chromatin organization. Predicted to act upstream of or within anterior/posterior pattern specification and camera-type eye morphogenesis. Predicted to be located in cytosol; nuclear body; and sex chromatin. Predicted to be part of PRC1 complex. Orthologous to human RING1 (ring finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 87.7), Kidney (RPKM 76.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4832013..4835516)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4830120..4833623)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (3812287..3815834, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RING1 protein levels were increased at day 3 after spinal cord injury and then decreased gradually.
Title: Spatiotemporal Patterns of RING1 Expression after Rat Spinal Cord Injury.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133333 (e-PCR)
- UniSTS:216616

BF393858 (e-PCR)
- UniSTS:244285

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in camera-type eye morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_positive_effect chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IEA Inferred from Electronic Annotation more info
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PRC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PcG protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in sex chromatin	IEA Inferred from Electronic Annotation more info
located_in sex chromatin	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RING1

Names: RING-type E3 ubiquitin transferase RING1; polycomb complex protein RING1

NP_997714.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212549.2 → NP_997714.2 E3 ubiquitin-protein ligase RING1

See identical proteins and their annotated locations for NP_997714.2

Status: VALIDATED

Source sequence(s)

BC098635, JAXUCZ010000020

UniProtKB/Swiss-Prot

Q4KMC1, Q63510, Q6MGB6

UniProtKB/TrEMBL

A0A0G2K5V5, A6JJG6

Related

ENSRNOP00000000543.5, ENSRNOT00000000543.6

Conserved Domains (2) summary

cd16739
Location:47 → 90

RING-HC_RING1; RING finger, HC subclass, found in really interesting new gene 1 protein (RING1) and similar proteins

cd17166
Location:261 → 400

RAWUL_RING1; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 1 protein (RING1)