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    Cnmd chondromodulin [ Mus musculus (house mouse) ]

    Gene ID: 16840, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cnmdprovided by MGI
    Official Full Name
    chondromodulinprovided by MGI
    Primary source
    MGI:MGI:1341171
    See related
    Ensembl:ENSMUSG00000022025 AllianceGenome:MGI:1341171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chmd; ChM-I; Lect1; Bricd3
    Summary
    Acts upstream of or within several processes, including endothelial cell morphogenesis; negative regulation of endothelial cell proliferation; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart valve; sensory organ; and skeleton. Orthologous to human CNMD (chondromodulin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 98.5), ovary adult (RPKM 23.0) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Cnmd in Genome Data Viewer
    Location:
    14 D3; 14 42.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79875126..79899596, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79637682..79662194, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene claspin homolog pseudogene Neighboring gene E74 like ETS transcription factor 1 Neighboring gene STARR-positive B cell enhancer mm9_chr14:79915269-79915570 Neighboring gene STARR-positive B cell enhancer ABC_E9411 Neighboring gene STARR-positive B cell enhancer ABC_E9903 Neighboring gene STARR-seq mESC enhancer starr_37267 Neighboring gene STARR-positive B cell enhancer ABC_E2430 Neighboring gene SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) Neighboring gene predicted gene, 41218 Neighboring gene RIKEN cDNA 4930452G13 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leukocyte cell-derived chemotaxin 1
    Names
    Chondromodulin 1
    chondromodulin-1
    chondromodulin-I
    leukocyte cell derived chemotaxin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310655.2NP_001297584.1  leukocyte cell-derived chemotaxin 1 isoform 1

      See identical proteins and their annotated locations for NP_001297584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122356, AC129216
      Consensus CDS
      CCDS79348.1
      UniProtKB/TrEMBL
      G5E8Z6
      Related
      ENSMUSP00000126958.2, ENSMUST00000165835.8
      Conserved Domains (1) summary
      smart01039
      Location:105201
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer
    2. NM_001424483.1NP_001411412.1  leukocyte cell-derived chemotaxin 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122356, AC129216
    3. NM_001424484.1NP_001411413.1  leukocyte cell-derived chemotaxin 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122356, AC129216
    4. NM_001424485.1NP_001411414.1  leukocyte cell-derived chemotaxin 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122356, AC129216
    5. NM_001424486.1NP_001411415.1  leukocyte cell-derived chemotaxin 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122356, AC129216
    6. NM_001424487.1NP_001411416.1  leukocyte cell-derived chemotaxin 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122356, AC129216
    7. NM_010701.4NP_034831.2  leukocyte cell-derived chemotaxin 1 isoform 2

      See identical proteins and their annotated locations for NP_034831.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) has the same N- and C- termini, but is four amino acids shorter than isoform 1.
      Source sequence(s)
      AC122356, AC129216
      Consensus CDS
      CCDS27302.1
      UniProtKB/Swiss-Prot
      Q80UX1, Q9CXU5, Q9Z1F6
      Related
      ENSMUSP00000022603.8, ENSMUST00000022603.8
      Conserved Domains (1) summary
      smart01039
      Location:105201
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      79875126..79899596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)