Myo1b myosin IB [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo1bprovided by MGI
Official Full Name: myosin IBprovided by MGI
Primary source: MGI:MGI:107752
See related: Ensembl:ENSMUSG00000018417 AllianceGenome:MGI:107752
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MMIa; MIH-L
Summary: Predicted to enable several functions, including actin filament binding activity; anion binding activity; and calmodulin binding activity. Acts upstream of or within transferrin transport. Located in brush border. Is expressed in 1st branchial arch mandibular component; central nervous system; facial prominence; head surface ectoderm; and sensory organ. Orthologous to human MYO1B (myosin IB). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 15.5), CNS E14 (RPKM 12.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 26.58 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (51788915..51955143, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (51749758..51916063, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging.
Title: Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging.
The senescent vascular smooth muscle cells showed elevated endogenous Arg-II and silencing Myo1b prevents Arg-II-mediated lysosomal positioning, dissociation of TSC from lysosome, mTORC1 activation and cell apoptosis.
Title: Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis.
a myosin 1 plays a major role in neuronal symmetry breaking and argue for a mechanical control of the actin cytoskeleton both in actin waves and in the growth cones by this myosin.
Title: Myosin 1b promotes axon formation by regulating actin wave propagation and growth cone dynamics.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF045565 (e-PCR)
- UniSTS:180002

RH126810 (e-PCR)
- UniSTS:209744

RH124549 (e-PCR)
- UniSTS:161371

AW557864 (e-PCR)
- UniSTS:178395

RH129682 (e-PCR)
- UniSTS:212979

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	ISO Inferred from Sequence Orthology more info
involved_in actin filament-based movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transferrin transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border	ISS Inferred from Sequence or Structural Similarity more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-Ib

Names: MMI-alpha; Myosin IA (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L); molecular motor; myosin I alpha; myosin-Ib

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161817.3 → NP_001155289.1 unconventional myosin-Ib isoform 1

See identical proteins and their annotated locations for NP_001155289.1

Status: VALIDATED

Source sequence(s)

AC108840, AC123555, AC138680

Consensus CDS

CCDS48254.1

UniProtKB/TrEMBL

E9Q580, Q7TQD7

Related

ENSMUSP00000018561.8, ENSMUST00000018561.14

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:941 → 1118

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001290982.2 → NP_001277911.1 unconventional myosin-Ib isoform 3

Status: VALIDATED

Source sequence(s)

AC108840, AC123555, AC138680

Consensus CDS

CCDS69887.1

UniProtKB/TrEMBL

E9Q580, E9QNH6

Related

ENSMUSP00000110184.3, ENSMUST00000114537.9

Conserved Domains (4) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

smart00242
Location:16 → 701

MYSc; Myosin. Large ATPases

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:883 → 1057

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
NM_001420362.1 → NP_001407291.1 unconventional myosin-Ib isoform 4

Status: VALIDATED

Source sequence(s)

AC108840, AC123555, AC138680
NM_001420363.1 → NP_001407292.1 unconventional myosin-Ib isoform 5

Status: VALIDATED

Source sequence(s)

AC108840, AC123555, AC138680
NM_001420364.1 → NP_001407293.1 unconventional myosin-Ib isoform 6

Status: VALIDATED

Source sequence(s)

AC108840, AC123555, AC138680
NM_010863.5 → NP_034993.2 unconventional myosin-Ib isoform 2

See identical proteins and their annotated locations for NP_034993.2

Status: VALIDATED

Source sequence(s)

AC108840, AC123555, AC138680

Consensus CDS

CCDS14942.1

UniProtKB/Swiss-Prot

P46735, P70244, Q80VD8

UniProtKB/TrEMBL

E9Q580

Related

ENSMUSP00000040447.8, ENSMUST00000046390.14

Conserved Domains (4) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

smart00242
Location:16 → 701

MYSc; Myosin. Large ATPases

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:912 → 1086

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

51788915..51955143 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495765.4 → XP_006495828.1 unconventional myosin-Ib isoform X1

See identical proteins and their annotated locations for XP_006495828.1

UniProtKB/TrEMBL

E9Q580

Conserved Domains (3) summary

smart00015
Location:751 → 773

IQ; Calmodulin-binding motif

cd01378
Location:29 → 690

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:943 → 1120

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_030252028.2 → XP_030107888.1 unconventional myosin-Ib isoform X2

UniProtKB/TrEMBL

E9Q580, Q7TQD7

Conserved Domains (3) summary

smart00015
Location:749 → 771

IQ; Calmodulin-binding motif

cd01378
Location:29 → 688

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:941 → 1118

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_006495769.3 → XP_006495832.1 unconventional myosin-Ib isoform X5

UniProtKB/TrEMBL

E9Q580

Conserved Domains (3) summary

smart00015
Location:630 → 652

IQ; Calmodulin-binding motif

cl22853
Location:1 → 569

Motor_domain; Myosin and Kinesin motor domain

pfam06017
Location:822 → 999

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_006495767.4 → XP_006495830.1 unconventional myosin-Ib isoform X4

UniProtKB/TrEMBL

E9Q580

Conserved Domains (3) summary

smart00015
Location:751 → 773

IQ; Calmodulin-binding motif

cd01378
Location:29 → 690

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:885 → 1062

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_006495766.4 → XP_006495829.1 unconventional myosin-Ib isoform X3

UniProtKB/TrEMBL

E9Q580

Conserved Domains (3) summary

smart00015
Location:751 → 773

IQ; Calmodulin-binding motif

cd01378
Location:29 → 690

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:914 → 1091

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
XM_006495764.4 → XP_006495827.1 unconventional myosin-Ib isoform X1

See identical proteins and their annotated locations for XP_006495827.1

UniProtKB/TrEMBL

E9Q580

Conserved Domains (3) summary

smart00015
Location:751 → 773

IQ; Calmodulin-binding motif

cd01378
Location:29 → 690

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:943 → 1120

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding