trim2 tripartite motif containing 2 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: trim2provided by Xenbase
Official Full Name: tripartite motif containing 2provided by Xenbase
Primary source: Xenbase:XB-GENE-942459
See related: Ensembl:ENSXETG00000001837 AllianceGenome:Xenbase:XB-GENE-942459
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary: Predicted to enable transferase activity and zinc ion binding activity. Predicted to act upstream of or within myeloid cell differentiation and primitive hemopoiesis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	1	NC_030677.2 (55132613..55206756, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	1	NC_030677.1 (45901107..45977892, complement)

Chromosome 1 - NC_030677.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within primitive hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tripartite motif-containing protein 2

NP_001005680.1

EC 2.3.2.27

XP_012814631.1

EC 2.3.2.27

XP_012814637.1

EC 2.3.2.27

XP_012814647.1

EC 2.3.2.27

XP_012814655.1

EC 2.3.2.27

XP_012814658.1

EC 2.3.2.27

XP_012814662.1

EC 2.3.2.27

XP_012814665.1

EC 2.3.2.27

XP_017947504.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005680.1 → NP_001005680.1 tripartite motif-containing protein 2

See identical proteins and their annotated locations for NP_001005680.1

Status: PROVISIONAL

Source sequence(s)

BC075100

UniProtKB/TrEMBL

F7AUU5, Q6DJS4

Related

ENSXETP00000055185.2, ENSXETT00000055185.4

Conserved Domains (7) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00336
Location:113 → 154

BBOX; B-Box-type zinc finger

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG3391
Location:547 → 751

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:23 → 66

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14960
Location:483 → 760

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:325 → 418

Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

Range

55132613..55206756 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_012959201.2 → XP_012814655.1 tripartite motif-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_012814655.1

UniProtKB/TrEMBL

F7AUU5, Q6DJS4

Conserved Domains (7) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00336
Location:113 → 154

BBOX; B-Box-type zinc finger

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG3391
Location:547 → 751

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:23 → 66

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14960
Location:483 → 760

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:325 → 418

Filamin; Filamin/ABP280 repeat
XM_018092015.2 → XP_017947504.1 tripartite motif-containing protein 2 isoform X1

UniProtKB/TrEMBL

F7AUU5, Q6DJS4
XM_012959183.3 → XP_012814637.1 tripartite motif-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_012814637.1

UniProtKB/TrEMBL

F7AUU5, Q6DJS4

Conserved Domains (7) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00336
Location:113 → 154

BBOX; B-Box-type zinc finger

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG3391
Location:547 → 751

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:23 → 66

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14960
Location:483 → 760

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:325 → 418

Filamin; Filamin/ABP280 repeat
XM_012959204.3 → XP_012814658.1 tripartite motif-containing protein 2 isoform X2

UniProtKB/TrEMBL

A0A8J0S9R4, F7AUU5

Conserved Domains (6) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:2 → 109

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:483 → 756

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:20 → 65

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:115 → 156

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_012959177.3 → XP_012814631.1 tripartite motif-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_012814631.1

UniProtKB/TrEMBL

F7AUU5, Q6DJS4

Conserved Domains (7) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00336
Location:113 → 154

BBOX; B-Box-type zinc finger

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG3391
Location:547 → 751

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:23 → 66

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14960
Location:483 → 760

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:325 → 418

Filamin; Filamin/ABP280 repeat
XM_012959211.3 → XP_012814665.1 tripartite motif-containing protein 2 isoform X4

UniProtKB/TrEMBL

A0A8J0SIU1, F7AUU5

Related

ENSXETP00000078169.1, ENSXETT00000085432.2

Conserved Domains (6) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG5432
Location:2 → 109

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cd14960
Location:471 → 744

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

cd16767
Location:20 → 65

RING-HC_TRIM2; RING finger, HC subclass, found in tripartite motif-containing protein 2 (TRIM2)

cd19824
Location:115 → 156

Bbox2_TRIM2_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 2 (TRIM2) and similar proteins
XM_012959208.3 → XP_012814662.1 tripartite motif-containing protein 2 isoform X3

UniProtKB/TrEMBL

A0A8J0SFW7, F7AUU5

Conserved Domains (7) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00336
Location:113 → 154

BBOX; B-Box-type zinc finger

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG3391
Location:535 → 739

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:23 → 66

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14960
Location:471 → 748

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:325 → 418

Filamin; Filamin/ABP280 repeat
XM_012959193.3 → XP_012814647.1 tripartite motif-containing protein 2 isoform X1

See identical proteins and their annotated locations for XP_012814647.1

UniProtKB/TrEMBL

F7AUU5, Q6DJS4

Conserved Domains (7) summary

smart00502
Location:161 → 287

BBC; B-Box C-terminal domain

smart00336
Location:113 → 154

BBOX; B-Box-type zinc finger

smart00557
Location:325 → 421

IG_FLMN; Filamin-type immunoglobulin domains

COG3391
Location:547 → 751

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:23 → 66

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14960
Location:483 → 760

NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins

pfam00630
Location:325 → 418

Filamin; Filamin/ABP280 repeat