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    Slc27a3 solute carrier family 27 (fatty acid transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 26568, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc27a3provided by MGI
    Official Full Name
    solute carrier family 27 (fatty acid transporter), member 3provided by MGI
    Primary source
    MGI:MGI:1347358
    See related
    Ensembl:ENSMUSG00000027932 AllianceGenome:MGI:1347358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FATP3; Acsvl3; FATP-3; Vlcs-3
    Summary
    Enables fatty-acyl-CoA synthase activity. Predicted to be involved in fatty acid transport and long-chain fatty acid metabolic process. Predicted to act upstream of or within acyl-CoA metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human SLC27A3 (solute carrier family 27 member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal adult (RPKM 148.3), ovary adult (RPKM 32.5) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc27a3 in Genome Data Viewer
    Location:
    3 F1; 3 39.22 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90292540..90298693, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90385230..90390835, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 4B Neighboring gene microRNA 7012 Neighboring gene STARR-positive B cell enhancer ABC_E28 Neighboring gene GATA zinc finger domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_08281 Neighboring gene STARR-positive B cell enhancer ABC_E9009 Neighboring gene STARR-seq mESC enhancer starr_08284 Neighboring gene integrator complex subunit 3 Neighboring gene STARR-seq mESC enhancer starr_08286 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90237240-90237349 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90237716-90237903 Neighboring gene STARR-seq mESC enhancer starr_08287 Neighboring gene STARR-seq mESC enhancer starr_08288 Neighboring gene STARR-positive B cell enhancer ABC_E6072 Neighboring gene STARR-positive B cell enhancer ABC_E56 Neighboring gene natriuretic peptide receptor 1 Neighboring gene nuclear encoded tRNA methionine 11 (anticodon CAT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. Pei Z, et al. J Biol Chem, 2004 Dec 24. PMID 15469937
    2. Differential expression of fatty acid transport proteins in epidermis and skin appendages. Schmuth M, et al. J Invest Dermatol, 2005 Dec. PMID 16354187
    3. mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle. Han LQ, et al. Genet Mol Res, 2010 Jun 29. PMID 20603810
    4. X-linked adrenoleukodystrophy: role of very long-chain acyl-CoA synthetases. Jia Z, et al. Mol Genet Metab, 2004 Sep-Oct. PMID 15464426
    5. A family of fatty acid transporters conserved from mycobacterium to man. Hirsch D, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671728, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle
      Title: mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle.
    2. studies cast doubt on the designation of very long-chain acyl-CoA synthetase 3 (ACSVL3) as a fatty acid transport protein
      Title: Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty-acyl-CoA synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acyl-CoA metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    NOT acts_upstream_of_or_within fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within long-chain fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    long-chain fatty acid transport protein 3
    Names
    arachidonate--CoA ligase
    long-chain-fatty-acid--CoA ligase
    mFLJ00207 protein
    solute carrier family 27 member 3
    very long-chain acyl-CoA synthetase homolog 3
    NP_001303617.1
    NP_036118.2
    XP_011238431.1
    XP_011238432.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316688.2 → NP_001303617.1  long-chain fatty acid transport protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145082
      UniProtKB/TrEMBL
      F7CPA3
      Related
      ENSMUSP00000122599.2, ENSMUST00000132041.2
      Conserved Domains (1) summary
      cl17068
      Location:64 → 528
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_011988.4 → NP_036118.2  long-chain fatty acid transport protein 3 isoform 1

      See identical proteins and their annotated locations for NP_036118.2

      Status: VALIDATED

      Source sequence(s)
      AC145082
      Consensus CDS
      CCDS17527.1
      UniProtKB/Swiss-Prot
      O88561, Q6PAU1, Q8BK70
      UniProtKB/TrEMBL
      B2RUG3, G3X8Y7
      Related
      ENSMUSP00000029541.6, ENSMUST00000029541.12
      Conserved Domains (2) summary
      PRK08279
      Location:62 → 666
      PRK08279; long-chain-acyl-CoA synthetase; Validated
      cl17068
      Location:88 → 657
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90292540..90298693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240129.4 → XP_011238431.1  long-chain fatty acid transport protein 3 isoform X1

      UniProtKB/Swiss-Prot
      O88561, Q6PAU1, Q8BK70
      UniProtKB/TrEMBL
      B2RUG3
      Conserved Domains (1) summary
      cl17068
      Location:87 → 609
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. XM_011240130.3 → XP_011238432.1  long-chain fatty acid transport protein 3 isoform X2

      Conserved Domains (1) summary
      cl17068
      Location:37 → 480
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88561.2 GenPept UniProtKB/Swiss-Prot:O88561

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