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    hhex hematopoietically expressed homeobox [ Danio rerio (zebrafish) ]

    Gene ID: 30098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hhexprovided by ZNC
    Official Full Name
    hematopoietically expressed homeoboxprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-980526-299
    See related
    AllianceGenome:ZFIN:ZDB-GENE-980526-299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hex
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including liver morphogenesis; negative regulation of transcription by RNA polymerase II; and regionalization. Acts upstream of or within with a positive effect on hepaticobiliary system development. Acts upstream of or within several processes, including circulatory system development; exocrine pancreas development; and positive regulation of endothelial cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; endocrine system; hepatoblast; and mesoderm. Orthologous to human HHEX (hematopoietically expressed homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See hhex in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (47663395..47670491)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (47692859..47699955, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496857 Neighboring gene fumarate hydratase Neighboring gene leucine zipper, putative tumor suppressor 2b Neighboring gene PDZ domain containing 7b Neighboring gene uncharacterized LOC110440159

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of hhex expression in the yolk syncytial layer, the potential Nieuwkoop center homolog in zebrafish. Bischof J, et al. Dev Biol, 2004 Dec 15. PMID 15581885
    2. Liver specification: a new role for Wnts in liver development. Burke ZD, et al. Curr Biol, 2006 Sep 5. PMID 16950093
    3. Bmp2 signaling regulates the hepatic versus pancreatic fate decision. Chung WS, et al. Dev Cell, 2008 Nov. PMID 19000838, Free PMC Article
    4. Igf2bp1 is required for hepatic outgrowth during early liver development in zebrafish. Wu J, et al. Gene, 2020 Jun 20. PMID 32240777
    5. Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors. Elsalini OA, et al. Dev Biol, 2003 Nov 1. PMID 14568547

    See all (136) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish.
      Title: Hhex and Prox1a synergistically dictate the hepatoblast to hepatocyte differentiation in zebrafish.
    2. Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration.
      Title: Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration.
    3. Hhex regulates the specification and growth of the hepatopancreatic ductal system.
      Title: Hhex regulates the specification and growth of the hepatopancreatic ductal system.
    4. Hhex, Cdx1b, Pdx1, and Sox9b form a genetic network governing the patterning and morphogenesis of the HPD and digestive tract systems in zebrafish.
      Title: Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1.
    5. Overall, the data show that HHEX controls blood vessel and lymphatic vessel formation by regulating the VEGFC/FLT4/PROX1 signaling axis.
      Title: HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development.
    6. hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
      Title: Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
    7. Data suggest that zebrafish hhex appears to be activated by Wnt/beta-catenin in the dorsal yolk syncytial layer, where bozozok acts in a permissive way to limit repression of hhex by Vega1 and Vega2.
      Title: Regulation of hhex expression in the yolk syncytial layer, the potential Nieuwkoop center homolog in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within exocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in hemangioblast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within_positive_effect hepaticobiliary system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in liver development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in liver morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		  
    acts_upstream_of_or_within positive regulation of endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    hematopoietically-expressed homeobox protein hhex
    Names
    homeobox protein hex

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130934.1 → NP_571009.1  hematopoietically-expressed homeobox protein hhex

      See identical proteins and their annotated locations for NP_571009.1

      Status: PROVISIONAL

      Source sequence(s)
      AF131070
      UniProtKB/Swiss-Prot
      Q9IAV3
      Conserved Domains (1) summary
      pfam00046
      Location:123 → 173
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      47663395..47670491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9IAV3.1 GenPept UniProtKB/Swiss-Prot:Q9IAV3

    Gene LinkOut

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    Research Materials