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    nosip nitric oxide synthase interacting protein [ Danio rerio (zebrafish) ]

    Gene ID: 492793, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nosipprovided by ZNC
    Official Full Name
    nitric oxide synthase interacting proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041114-146
    See related
    Ensembl:ENSDARG00000037958 AllianceGenome:ZFIN:ZDB-GENE-041114-146
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb80a11; zgc:101669
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human NOSIP (nitric oxide synthase interacting protein). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See nosip in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (32532589..32536378)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (32400857..32404664)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 4a Neighboring gene sarcoplasmic reticulum histidine-rich calcium-binding protein Neighboring gene reticulocalbin 3, EF-hand calcium binding domain Neighboring gene paired box 10 Neighboring gene BCL2 like 12 Neighboring gene microRNA 150

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Shedding a Light on Dark Genes: A Comparative Expression Study of PRR12 Orthologues during Zebrafish Development. Muscò A, et al. Genes (Basel), 2024 Apr 15. PMID 38674426, Free PMC Article
    2. Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling. Levi L, et al. BMC Genomics, 2009 Mar 31. PMID 19335895, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nitric oxide synthase-interacting protein
    Names
    E3 ubiquitin-protein ligase NOSIP
    RING-type E3 ubiquitin transferase NOSIP
    NP_001007435.1
    XP_005164079.1
    XP_009297811.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007434.1 → NP_001007435.1  nitric oxide synthase-interacting protein

      See identical proteins and their annotated locations for NP_001007435.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085409
      UniProtKB/Swiss-Prot
      Q5U3S7
      UniProtKB/TrEMBL
      B2GNS3
      Related
      ENSDARP00000055311.6, ENSDART00000055312.8
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cl17238
      Location:224 → 279
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      32532589..32536378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009299536.4 → XP_009297811.1  nitric oxide synthase-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_009297811.1

      UniProtKB/Swiss-Prot
      Q5U3S7
      UniProtKB/TrEMBL
      B2GNS3
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cl17238
      Location:224 → 279
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. XM_005164022.5 → XP_005164079.1  nitric oxide synthase-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_005164079.1

      UniProtKB/Swiss-Prot
      Q5U3S7
      UniProtKB/TrEMBL
      B2GNS3
      Related
      ENSDARP00000139361.1, ENSDART00000165909.3
      Conserved Domains (2) summary
      pfam15906
      Location:4 → 78
      zf-NOSIP; Zinc-finger of nitric oxide synthase-interacting protein
      cl17238
      Location:224 → 279
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394535.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      19662..23395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U3S7.1 GenPept UniProtKB/Swiss-Prot:Q5U3S7

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